Probing intratumoral metabolic compartmentalisation in fumarate hydratase-deficient renal cancer using clinical hyperpolarised 13C-MRI and mass spectrometry imaging
Ines Horvat-Menih, Ruth Casey, James Denholm, Gregory Hamm, Heather Hulme, John Gallon, Alixander S Khan, Joshua Kaggie, Andrew B Gill, Andrew N Priest, Joao A G Duarte, Cissy Yong, Cara Brodie, James Whitworth, Simon T Barry, Richard J A Goodwin, Shubha Anand, Marc Dodd, Katherine Honan, Sarah J Welsh, Anne Y Warren, Tevita Aho, Grant D Stewart, Thomas J Mitchell, Mary A McLean, Ferdia A Gallagher
{"title":"Probing intratumoral metabolic compartmentalisation in fumarate hydratase-deficient renal cancer using clinical hyperpolarised 13C-MRI and mass spectrometry imaging","authors":"Ines Horvat-Menih, Ruth Casey, James Denholm, Gregory Hamm, Heather Hulme, John Gallon, Alixander S Khan, Joshua Kaggie, Andrew B Gill, Andrew N Priest, Joao A G Duarte, Cissy Yong, Cara Brodie, James Whitworth, Simon T Barry, Richard J A Goodwin, Shubha Anand, Marc Dodd, Katherine Honan, Sarah J Welsh, Anne Y Warren, Tevita Aho, Grant D Stewart, Thomas J Mitchell, Mary A McLean, Ferdia A Gallagher","doi":"10.1101/2024.05.06.24306817","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accurately phenotype tumour metabolism and its heterogeneity.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Radiology and Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.05.06.24306817","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accurately phenotype tumour metabolism and its heterogeneity.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
