Synthesis and Biological Applications of Coumarinyl-Chalcones

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC Current Organic Chemistry Pub Date : 2024-05-13 DOI:10.2174/0113852728248318240418092208
Sayed K. Ramadan, Sameh A. Rizk, Eman A.E. El-Helw
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Abstract

: This survey provides information on the synthesis and biological applications of coumarinylchalcones. Chalcones are unsaturated ketones involving the reactive keto-ethylenic group (CO-CH=CH). Chalcones are naturally abundant in many medical plants, including vegetables, fruits, and foods. Natural and synthetic chalcone compounds exhibit a broad spectrum of biological properties like anticancer, antiinflammatory, anti-HIV, antioxidant, antimalarial, and antimicrobial. Some conventional, microwave, and grinding techniques have been utilized for the synthesis of chalcones. Noteworthy, the Claisen-Schmidt condensation reaction remains the most popular and effective method for synthesis. It summarizes information about its synthetic methods as building blocks in some reactions like cyclization reactions and medical applications. This review article presents an overview of approaches and biological data for chalcones bearing a coumarin scaffold.
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香豆素-查耳酮的合成与生物应用
:本调查报告提供了香豆素基查尔酮的合成和生物应用方面的信息。查耳酮是不饱和酮类化合物,含有活性酮乙烯基(CO-CH=CH)。在许多医用植物(包括蔬菜、水果和食品)中,查尔酮的天然含量非常丰富。天然和合成查尔酮化合物具有广泛的生物特性,如抗癌、抗炎、抗艾滋病毒、抗氧化、抗疟和抗菌。一些常规、微波和研磨技术已被用于合成查耳酮。值得注意的是,克莱森-施密特缩合反应仍然是最常用、最有效的合成方法。这篇文章总结了有关其合成方法的信息,将其作为一些反应(如环化反应和医学应用)的构件。这篇综述文章概述了带有香豆素支架的查耳酮的合成方法和生物学数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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