Risk of Dementia in Korean Vietnam War Veterans

Wanhyung Lee, Seunghyun Lee, S.-K. Kang, Won-Jun Choi
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Abstract

Background

The number of cases of all types of dementia is increasing, and a significant increase in prevalence has been noted among veterans. Evidence of an association between dementia and exposure to chemicals such as Agent Orange from the Vietnam War is still limited, and there is a reported lack of awareness.

Objective

This study aimed to investigate the risk of dementia among Vietnam War veterans in Korea.

Design

This retrospective longitudinal study compared the incidence of dementia between Vietnam War veterans and the general population.

Setting

This study used data from the nationally representative Korean Vietnam War Veterans’ Health Study Cohort, a combined dataset sourced from the Ministry of Patriots and Veterans Affairs in Korea and the National Health Insurance Sharing Service database.

Participants

There were 191,272 Vietnam War veterans and 1,000,320 people of different ages, sexes, and residences. matched control in 2002. The total number of person-years were 18,543,181.

Measurements

The dementia group included participants who had visited a medical facility with any of the following ICD-10 codes in the follow-up periods: “F00 Dementia in Alzheimer’s disease,” “F01 Vascular dementia,” “F02 Dementia in other diseases classified elsewhere,” or “F03 Unspecified dementia.”

Results

The incidence rate ratio for all types of dementia was 1.16, with higher ratios observed for vascular and unspecified dementia, particularly in the younger age groups. There was a significant increase in the risk of dementia, Alzheimer’s disease, vascular dementia, and unspecified dementia.

Conclusion

Vietnam War veterans showed an increased risk for all types of dementia. These findings are hypothesized to be due to the effects of the chemicals used during the Vietnam War, which can cause a variety of neurodegenerative diseases. Further studies are warranted to investigate the potential health determinants related to the Vietnam War, focusing on the neurodegenerative effects.

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韩国越战退伍军人患痴呆症的风险
背景所有类型痴呆症的病例数都在增加,退伍军人中的发病率也显著增加。痴呆症与越战期间接触橙剂等化学物质有关的证据仍然有限,而且据报道人们对此缺乏认识。本研究旨在调查韩国越战退伍军人患痴呆症的风险。背景本研究使用了具有全国代表性的韩国越战退伍军人健康研究队列的数据,该研究队列是由韩国爱国者和退伍军人事务部以及国家健康保险共享服务数据库共同提供的数据集。参与者2002年有191272名越战退伍军人和100320名不同年龄、性别和居住地的人。痴呆症组包括在随访期间曾在医疗机构就诊并带有以下任何一种 ICD-10 编码的参与者:"F00 阿尔茨海默氏症中的痴呆症"、"F00 阿尔茨海默氏症中的痴呆症 "和 "F00 阿尔茨海默氏症中的痴呆症":"结果所有类型痴呆症的发病率比为1.16,其中血管性痴呆症和不明原因痴呆症的发病率比更高,尤其是在年轻群体中。越战退伍军人患痴呆症、阿尔茨海默病、血管性痴呆症和不明痴呆症的风险明显增加。这些发现可能是由于越战期间使用的化学物质的影响,这些化学物质可导致多种神经退行性疾病。有必要开展进一步的研究,调查与越战有关的潜在健康决定因素,重点是神经退行性疾病的影响。
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The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
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期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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