Estimating Socio-Economic Status for Alzheimer’s Disease Trials

Dorene M. Rentz, J. D. Grill, D. P. Molina-Henry, G. A. Jicha, M. S. Rafii, A. Liu, R. A. Sperling, P. S. Aisen, R. Raman
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Abstract

Introduction

Metrics of a participant’s socioeconomic status (SES) are not routinely collected or standardized in clinical trials. This omission limits the ability to evaluate the generalizability of trial results and restricts clinicians from confidently interpreting the efficacy of new treatments across important sub-populations.

Methods

We adapted an SES measure of social disparity; the Hollingshead Two Factor Index of Social Position, which combines education and occupation into a single metric. We modernized the 1965 occupations to reflect the 2017 careers tabulated by the US Bureau of Labor Statistics. We currently use this adapted measure in Alzheimer’s Clinical Trials Consortium studies.

Results

We present the revised table of occupations. We found that the collection of SES data using the modified Hollingshead was feasible in a multi-site clinical trial and scores were distributed across all SES strata.

Discussion

The modified Hollingshead provides a standardized method for collecting SES information, enabling data aggregation, monitoring, and reporting.

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估算阿尔茨海默病试验的社会经济状况
引言 临床试验中没有常规收集或标准化受试者的社会经济地位(SES)指标。这种遗漏限制了评估试验结果普适性的能力,也限制了临床医生自信地解释新疗法在重要亚人群中的疗效。方法我们改编了一种社会经济地位衡量标准,即霍林斯海德社会地位双因素指数(Hollingshead Two Factor Index of Social Position),它将教育和职业结合为一个单一指标。我们对 1965 年的职业进行了更新,以反映美国劳工统计局列出的 2017 年职业。目前,我们在阿尔茨海默氏症临床试验联盟的研究中使用了这一经过调整的衡量标准。我们发现,在多地点临床试验中使用修改后的 Hollingshead 收集 SES 数据是可行的,而且得分分布于所有 SES 阶层。讨论修改后的 Hollingshead 提供了一种收集 SES 信息的标准化方法,使数据汇总、监测和报告成为可能。
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The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
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9.20
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期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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