Triglyceride-Glucose Index Predicts Major Adverse Cardiovascular and Cerebrovascular Events in Patients with Atrial Fibrillation

IF 1.2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS International heart journal Pub Date : 2024-05-15 DOI:10.1536/ihj.23-413

Chunhui Yin, Qiqi Hou, Qi Qi, Quanle Han, Xiaoyao Wang, Shouling Wu, Kangbo Li

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Abstract

This study aimed to explore the relationship between the trajectory of the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) in patients with atrial fibrillation (AF).

This prospective study included 1979 patients with AF, who were initially selected from the Kailuan study. Patients of AF were split into four groups according to the value of TyG index. The clinical endpoint was MACCE, including myocardial infarction and ischemic stroke. Cox proportional hazard models were employed to examine the hazard ratio (HR) and 95% confidence interval (CI) for MACCE in various trajectory groups.

The mean age of all patients with AF was 67.65 ± 11.15 years, and 1752 (88.53%) were male. Over a median follow-up duration of 5.31 years, in total 227 MACCE were recorded. MACCE cumulative incidence in Quartile 4 (26.96%) was significantly higher than those in other quartiles (P = 0.023). Multivariate Cox proportional hazards regression analysis showed that a higher TyG index (Quartile 4) was significantly and positively linked to MACCE in patients with AF (P = 0.023, HR: 2.103; 95% CI: 1.107-3.994).

The evaluated TyG index is significantly associated with an increased risk of MACCE in patients with AF.

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甘油三酯-葡萄糖指数可预测心房颤动患者的主要不良心血管和脑血管事件

本研究旨在探讨甘油三酯-葡萄糖（TyG）指数的变化轨迹与心房颤动（房颤）患者主要不良心脑血管事件（MACCE）发生率之间的关系。根据TyG指数值，房颤患者被分为四组。临床终点为MACCE，包括心肌梗死和缺血性卒中。所有房颤患者的平均年龄为（67.65±11.15）岁，男性患者为 1752 人（88.53%）。中位随访时间为 5.31 年，共记录到 227 例 MACCE。四分位数 4 的 MACCE 累计发生率（26.96%）明显高于其他四分位数（P = 0.023）。多变量 Cox 比例危险回归分析显示，TyG 指数越高（四分位数 4）与房颤患者的 MACCE 呈显著正相关（P = 0.023，HR：2.103；95% CI：1.107-3.994）。

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来源期刊

International heart journal 医学-心血管系统

CiteScore

2.50

自引率

6.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Authors of research articles should disclose at the time of submission any financial arrangement they may have with a company whose product figures prominently in the submitted manuscript or with a company making a competing product. Such information will be held in confidence while the paper is under review and will not influence the editorial decision, but if the article is accepted for publication, the editors will usually discuss with the authors the manner in which such information is to be communicated to the reader.