Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-05-16 DOI:10.1111/imr.13345
Coco M. Fuhri Snethlage, Douwe de Wit, Koen Wortelboer, Elena Rampanelli, Nordin M. J. Hanssen, Max Nieuwdorp
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Abstract

Type 1 diabetes (T1D) is a chronic autoimmune disease targeting insulin-producing pancreatic beta cells. T1D is a multifactorial disease incorporating genetic and environmental factors. In recent years, the advances in high-throughput sequencing have allowed researchers to elucidate the changes in the gut microbiota taxonomy and functional capacity that accompany T1D development. An increasing number of studies have shown a role of the gut microbiota in mediating immune responses in health and disease, including autoimmunity. Fecal microbiota transplantations (FMT) have been largely used in murine models to prove a causal role of the gut microbiome in disease progression and have been shown to be a safe and effective treatment in inflammatory human diseases. In this review, we summarize and discuss recent research regarding the gut microbiota–host interactions in T1D, the current advancement in therapies for T1D, and the usefulness of FMT studies to explore microbiota–host immunity encounters in murine models and to shape the course of human type 1 diabetes.

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粪便微生物群移植能否调节 1 型糖尿病患者的自身免疫反应?
1 型糖尿病(T1D)是一种针对产生胰岛素的胰岛β细胞的慢性自身免疫性疾病。T1D 是一种包含遗传和环境因素的多因素疾病。近年来,高通量测序技术的进步使研究人员得以阐明伴随 T1D 发病的肠道微生物群分类和功能能力的变化。越来越多的研究表明,肠道微生物群在介导健康和疾病(包括自身免疫)的免疫反应中发挥作用。粪便微生物群移植(FMT)主要用于小鼠模型,以证明肠道微生物群在疾病进展中的因果作用,并已被证明是治疗人类炎症性疾病的一种安全有效的方法。在这篇综述中,我们总结并讨论了有关 T1D 肠道微生物群与宿主相互作用的最新研究、目前 T1D 治疗方法的进展以及 FMT 研究在探索小鼠模型中微生物群与宿主免疫相遇和塑造人类 1 型糖尿病病程方面的作用。
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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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