Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits.

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL SAGE Open Medicine Pub Date : 2024-05-14 eCollection Date: 2024-01-01 DOI:10.1177/20503121241241922

Holiness S A Olasore, Tolulope A Oyedeji, Joseph O Faleti, Omobola I Ogundele, Anthony A Olashore

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Abstract

Objective: This study aimed to find a potential association between the DRD2 Taq1A gene polymorphism (rs1800497 C32806T) and personality traits.

Methods: In all, 249 youths were recruited for this study. The Short-form Revised Eysenck Personality Questionnaire was administered to assess personality traits. The participants were genotyped for the DRD2 Taq1A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis was carried out to find a possible association between the genotypes and aspects of personality traits assessed.

Results: The frequencies of the A1 and A2 alleles in our sampled population were 215 (43.2%) and 283 (56.8%), while the frequencies of A1A1, A1A2, and A2A2 were 67 (26.9%), 81 (32.5%), and 101 (40.6%), respectively. The study population was not in Hardy-Weinberg equilibrium (χ² = 17.64, p < 0.001). The A2 allele was significantly associated with extraversion. Although this allele was also associated with neuroticism, psychoticism, and lie, the association was not significant.

Conclusion: The A2 allele of the DRD2 Taq1A polymorphism was found to be more associated with extraversion, as measured by the Short-form Revised Eysenck Personality Questionnaire.

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多巴胺受体 D2 Taq IA 基因多态性（rs1800497）与人格特质的关系。

研究目的本研究旨在发现 DRD2 Taq1A 基因多态性（rs1800497 C32806T）与人格特质之间的潜在关联：本研究共招募了 249 名青少年。方法：本研究共招募了 249 名青少年，采用简式艾森克人格问卷（Short-form Revised Eysenck Personality Questionnaire）评估他们的人格特质。采用聚合酶链式反应-限制性片段长度多态性方法对参与者进行 DRD2 Taq1A 多态性基因分型。研究人员进行了统计分析，以找出基因型与所评估的人格特质之间可能存在的关联：在我们的抽样人群中，A1 和 A2 等位基因的频率分别为 215（43.2%）和 283（56.8%），而 A1A1、A1A2 和 A2A2 的频率分别为 67（26.9%）、81（32.5%）和 101（40.6%）。研究人群并不处于哈代-温伯格平衡状态（χ2 = 17.64，p 结论：A1A1、A1A2 和 A2A2 的等位基因均不处于哈代-温伯格平衡状态：研究发现，DRD2 Taq1A 多态性的 A2 等位基因与外向性更相关，外向性是由简式修订版艾森克人格问卷（Short-form Revised Eysenck Personality Questionnaire）测量的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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