Safety of RNA-Dependent RNA Polymerase Inhibitors, Molnupiravir and VV116, for Oral Treatment of COVID-19: A Meta-Analysis.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-05-01 DOI:10.30476/IJMS.2024.99837.3196
Zequn Zheng, Jiaozhi Zhou, Yongfei Song
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引用次数: 0

Abstract

Background: The RNA-dependent RNA polymerase (RdRp) inhibitors, molnupiravir and VV116, have the potential to maximize clinical benefits in the oral treatment of COVID-19. Subjects who consume these drugs may experience an increased incidence of adverse events. This study aimed to evaluate the safety profile of molnupiravir and VV116.

Methods: A comprehensive search of scientific and medical databases, such as PubMed Central/Medline, Embase, Web of Science, and Cochrane Library, was conducted to find relevant articles in English from January 2020 to June 2023. Any kind of adverse events reported in the study were pooled and analyzed in the drug group versus the control group. Estimates of risk effects were summarized through the random effects model using Review Manager version 5.2, and sensitivity analysis was performed by Stata 17.0 software.

Results: Fifteen studies involving 32,796 subjects were included. Eleven studies were placebo-controlled, and four were Paxlovid-controlled. Twelve studies reported adverse events for molnupiravir, and three studies described adverse events for VV116. The total odds ratio (OR) for adverse events in the RdRp inhibitor versus the placebo-controlled group was 1.01 (95% CI=0.84-1.22; I2=26%), P=0.88. The total OR for adverse events in the RdRp inhibitor versus the Paxlovid-controlled group was 0.32 (95% CI=0.16-0.65; I2=87%), P=0.002. Individual drug subgroup analysis in the placebo-controlled study showed that compared with the placebo group, a total OR for adverse events was 0.97 (95% CI, 0.85-1.10; I2=0%) in the molnupiravir group and 3.77 (95% CI=0.08-175.77; I2=85%) in the VV116 group.

Conclusion: The RdRp inhibitors molnupiravir and VV116 are safe for oral treatment of COVID-19. Further evidence is necessary that RdRp inhibitors have a higher safety profile than Paxlovid.

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RNA依赖性RNA聚合酶抑制剂Molnupiravir和VV116口服治疗COVID-19的安全性:元分析。
背景:RNA依赖性RNA聚合酶(RdRp)抑制剂、molnupiravir和VV116有可能在COVID-19的口服治疗中最大限度地提高临床疗效。服用这些药物的受试者可能会增加不良反应的发生率。本研究旨在评估molnupiravir和VV116的安全性:方法:对 PubMed Central/Medline、Embase、Web of Science 和 Cochrane Library 等科学和医学数据库进行了全面检索,以查找 2020 年 1 月至 2023 年 6 月期间的相关英文文章。研究中报告的任何类型的不良事件都被汇总起来,并在药物组与对照组中进行分析。使用Review Manager 5.2版通过随机效应模型对风险效应进行估计,并使用Stata 17.0软件进行敏感性分析:结果:共纳入 15 项研究,涉及 32796 名受试者。其中 11 项研究为安慰剂对照研究,4 项为 Paxlovid 对照研究。12项研究报告了莫仑吡韦的不良事件,3项研究描述了VV116的不良事件。RdRp抑制剂组与安慰剂对照组发生不良事件的总几率比(OR)为1.01(95% CI=0.84-1.22;I2=26%),P=0.88。RdRp抑制剂对照组与Paxlovid对照组的不良事件总OR值为0.32(95% CI=0.16-0.65;I2=87%),P=0.002。安慰剂对照研究中的单药亚组分析显示,与安慰剂组相比,molnupiravir组不良事件的总OR为0.97(95% CI,0.85-1.10;I2=0%),VV116组为3.77(95% CI=0.08-175.77;I2=85%):结论:RdRp抑制剂molnupiravir和VV116口服治疗COVID-19是安全的。结论:RdRp抑制剂molnupiravir和VV116用于口服治疗COVID-19是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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