Metabolic dependencies of acute myeloid leukemia stem cells.

IF 1.7 4区 医学 Q3 HEMATOLOGY International Journal of Hematology Pub Date : 2024-10-01 Epub Date: 2024-05-15 DOI:10.1007/s12185-024-03789-x
Xiangguo Shi, Mengdie Feng, Daisuke Nakada
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Abstract

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem cells (LSCs) that are implicated in AML development, chemoresistance, and relapse. An emerging area of research in AML focuses on identifying and targeting the aberrant metabolism in LSCs. Dysregulated metabolism is involved in sustaining functional properties of LSCs, impeding myeloid differentiation, and evading programmed cell death, both in the process of leukemogenesis and in response to chemotherapy. This review discusses recent discoveries regarding the aberrant metabolic processes of AML LSCs that have begun to change the therapeutic landscape of AML.

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急性髓性白血病干细胞的代谢依赖性
急性髓性白血病(AML)是一种异质性血液系统恶性肿瘤,主要由被称为白血病干细胞(LSCs)的未成熟AML细胞群驱动。急性髓细胞性白血病的一个新兴研究领域是识别和靶向治疗白血病干细胞的异常代谢。失调的新陈代谢在白血病发生过程和化疗反应中参与维持造血干细胞的功能特性、阻碍髓系分化和逃避程序性细胞死亡。本综述将讨论有关急性髓细胞性白血病造血干细胞异常代谢过程的最新发现,这些发现已开始改变急性髓细胞性白血病的治疗格局。
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来源期刊
CiteScore
3.90
自引率
4.80%
发文量
223
审稿时长
6 months
期刊介绍: The International Journal of Hematology, the official journal of the Japanese Society of Hematology, has a long history of publishing leading research in hematology. The journal comprises articles that contribute to progress in research not only in basic hematology but also in clinical hematology, aiming to cover all aspects of this field, namely, erythrocytes, leukocytes and hematopoiesis, hemostasis, thrombosis and vascular biology, hematological malignancies, transplantation, and cell therapy. The expanded [Progress in Hematology] section integrates such relevant fields as the cell biology of stem cells and cancer cells, and clinical research in inflammation, cancer, and thrombosis. Reports on results of clinical trials are also included, thus contributing to the aim of fostering communication among researchers in the growing field of modern hematology. The journal provides the best of up-to-date information on modern hematology, presenting readers with high-impact, original work focusing on pivotal issues.
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