Can transcriptomics guide the management of SLE-associated APS?

IF 29.4 1区 医学 Q1 RHEUMATOLOGY Nature Reviews Rheumatology Pub Date : 2024-05-16 DOI:10.1038/s41584-024-01123-7
Jason S. Knight, Maria G. Tektonidou
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引用次数: 0

Abstract

The management of antiphospholipid syndrome is hindered by heterogeneous clinical presentations. Whole-blood transcriptomics have the potential to identify previously unknown disease endotypes, which could inform new treatment strategies. However, such hypothesis-generating data must still account for the results of randomized clinical trials, such as those focused on direct oral anticoagulants in APS.
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转录组学能否指导系统性红斑狼疮相关 APS 的治疗?
抗磷脂综合征的治疗因临床表现的异质性而受到阻碍。全血转录组学有可能确定之前未知的疾病内型,从而为新的治疗策略提供依据。然而,这些假设产生的数据仍必须考虑到随机临床试验的结果,如针对 APS 的直接口服抗凝剂试验。
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来源期刊
Nature Reviews Rheumatology
Nature Reviews Rheumatology 医学-风湿病学
CiteScore
29.90
自引率
0.90%
发文量
137
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.
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