Early detection of pancreatic cancer in the era of precision medicine

IF 2.3 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Abdominal Radiology Pub Date : 2024-05-18 DOI:10.1007/s00261-024-04358-w
Taha M. Ahmed, Satomi Kawamoto, Felipe Lopez-Ramirez, Mohammad Yasrab, Ralph H. Hruban, Elliot K. Fishman, Linda C. Chu
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality and it is often diagnosed at advanced stages due to non-specific clinical presentation. Disease detection at localized disease stage followed by surgical resection remains the only potentially curative treatment. In this era of precision medicine, a multifaceted approach to early detection of PDAC includes targeted screening in high-risk populations, serum biomarkers and “liquid biopsies”, and artificial intelligence augmented tumor detection from radiologic examinations. In this review, we will review these emerging techniques in the early detection of PDAC.

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精准医疗时代的胰腺癌早期检测。
胰腺导管腺癌(PDAC)是导致癌症相关死亡的第三大原因,由于临床表现无特异性,通常在晚期才被确诊。在局部疾病阶段发现疾病并进行手术切除仍是唯一可能治愈的治疗方法。在这个精准医学时代,早期检测 PDAC 的多方面方法包括对高危人群进行有针对性的筛查、血清生物标志物和 "液体活检",以及从放射检查中进行人工智能增强肿瘤检测。在本综述中,我们将回顾这些用于早期检测 PDAC 的新兴技术。
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来源期刊
Abdominal Radiology
Abdominal Radiology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.20
自引率
8.30%
发文量
334
期刊介绍: Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section. Reasons to Publish Your Article in Abdominal Radiology: · Official journal of the Society of Abdominal Radiology (SAR) · Published in Cooperation with: European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Urogenital Radiology (ESUR) Asian Society of Abdominal Radiology (ASAR) · Efficient handling and Expeditious review · Author feedback is provided in a mentoring style · Global readership · Readers can earn CME credits
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