Validation of a German version of the dementia screening questionnaire for individuals with intellectual disabilities (DSQIID-G) in Down's syndrome

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL Journal of Intellectual Disability Research Pub Date : 2024-05-17 DOI:10.1111/jir.13144

G. Nuebling, O. Wagemann, S. Deb, E. Wlasich, S. V. Loosli, K. Sandkühler, A. Stockbauer, C. Prix, J. Levin

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Abstract

Background

People with Down's syndrome (DS) are at high risk of developing Alzheimer dementia (DS-AD) due to a triplication of the amyloid precursor protein gene. While several tools to diagnose and screen for DS-AD, such as the dementia screening questionnaire for individuals with intellectual disabilities (DSQIID), are available in English, validated German versions of such instruments are scarce.

Methods

A German version of the DSQIID questionnaire (DSQIID-G) was completed by caregivers before attending our specialist outpatient department for DS-AD. All participants were assessed blind to DSQIID-G scoring using clinical and neuropsychological examinations, including the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS). ICD-10 and amyloid/tau/neurodegeneration (A/T/N) criteria were applied to detect and categorise cognitive decline.

Results

Of 86 participants, 43 (50%) showed evidence of cognitive decline. A definite diagnosis of DS-AD was reached in 17 (19.8%) and mild cognitive impairment in seven (8.3%) participants. Secondary causes of cognitive decline were determined among 13 (15.1%) participants, and in six (7%) cases, the diagnosis remained unclassifiable due to co-morbidities. Compared with cognitively stable individuals, participants with cognitive decline (n = 43) displayed higher DSQIID-G total scores [median (range): 3 (0–21) vs. 19 (0–48), P < 0.001]. A total score of >7 provided a sensitivity of 0.94 against a specificity of 0.76, to discriminate DS-AD and participants without cognitive decline according to ROC analysis. The convergent validity against the CAMDEX-DS interview score was good (r = 0.74), and split-half reliability (r = 0.96), internal consistency (Cronbach's α r = 0.96), test–retest reliability (r = 0.88) (n = 25) and interrater reliability (r = 0.81) (n = 31) were excellent.

Conclusions

The DSQIID-G showed excellent psychometric properties, including concurrent and internal validity and reliability. The cut-off value for screening was lower than in the original English validation study. For a screening instrument like DSQIID-G, a lower cut-off is preferable to increase case detection.

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德文版唐氏综合征智障人士痴呆症筛查问卷（DSQIID-G）的验证。

背景：由于淀粉样前体蛋白基因的三倍复制，唐氏综合征（DS）患者患阿尔茨海默痴呆症（DS-AD）的风险很高。虽然有几种诊断和筛查 DS-AD 的工具，如智障人士痴呆症筛查问卷（DSQIID），有英文版，但经过验证的德文版此类工具却很少：方法：护理人员在前往我们的 DS-AD 专科门诊就诊之前，需要填写德文版的 DSQIID 问卷（DSQIID-G）。所有参与者均通过临床和神经心理学检查（包括剑桥唐氏综合征和其他智障老年人精神障碍检查（CAMDEX-DS））进行了盲法评估。采用ICD-10和淀粉样蛋白/Tau/神经变性（A/T/N）标准检测认知能力下降并进行分类：在 86 名参与者中，有 43 人（50%）出现认知能力下降。有 17 人（19.8%）确诊为 DS-AD，7 人（8.3%）确诊为轻度认知障碍。13名参与者（15.1%）确定了认知能力下降的次要原因，6名参与者（7%）因合并其他疾病而无法确诊。与认知能力稳定的人相比，认知能力下降的参与者（n = 43）显示出更高的 DSQIID-G 总分[中位数（范围）：3（0-21） vs. 19]：根据 ROC 分析，DS-AD 与无认知功能衰退者的区分灵敏度为 0.94，特异度为 0.76。DSQIID-G与CAMDEX-DS访谈得分的收敛效度良好（r = 0.74），分半信度（r = 0.96）、内部一致性（Cronbach's α r = 0.96）、测试-再测信度（r = 0.88）（n = 25）和施测者间信度（r = 0.81）（n = 31）均非常出色：结论：DSQIID-G显示出良好的心理测量特性，包括并发和内部效度和信度。筛查的临界值低于最初的英语验证研究。对于像 DSQIID-G 这样的筛查工具来说，较低的临界值更有利于提高病例检出率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Intellectual Disability Research Multiple-

CiteScore

5.60

自引率

5.60%

发文量

期刊介绍： The Journal of Intellectual Disability Research is devoted exclusively to the scientific study of intellectual disability and publishes papers reporting original observations in this field. The subject matter is broad and includes, but is not restricted to, findings from biological, educational, genetic, medical, psychiatric, psychological and sociological studies, and ethical, philosophical, and legal contributions that increase knowledge on the treatment and prevention of intellectual disability and of associated impairments and disabilities, and/or inform public policy and practice. Expert reviews on themes in which recent research has produced notable advances will be included. Such reviews will normally be by invitation.