NEUT-RI, a surrogate marker of NETosis is lower in patients with strong IgM antiphospholipid antibodies.

IF 2.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Thrombosis and Thrombolysis Pub Date : 2024-08-01 Epub Date: 2024-05-18 DOI:10.1007/s11239-024-03001-1

Sylvie Bouvier, Mathieu Fortier, Eva Nouvellon, Ariane Olivan, Mathias Chéa, Jean-Christophe Gris

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Abstract

Background: Antiphospholipid antibody syndrome (APS) is an acquired autoimmune disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy complications. Recently, thrombotic APS was linked to increased neutrophil extracellular traps (NET) formation, suggesting an association between NETs and the severity of APS-related thrombosis.

Methods: We performed a retrospective study on patients tested for presence of antiphospholipid antibodies (990 negative and 374 positive) to evaluate the association between the neutrophil activation state, estimated by the neutrophil reactive index (NEU-RI), a parameter routinely available from some haematology analysers, and antiphospholipid antibodies.

Results: We do not observe a difference in NEU-RI values between positive and negative patients globally. However, interestingly, we highlight an association between high titers of IgM and low NEU-RI values indicating a lower neutrophil activation.

Conclusion: Our data are in line with the recent questioning about the putative clinical consistency of positive solid-phase aPL IgM.

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在 IgM 抗磷脂抗体较强的患者中，NEUT-RI（NETosis 的替代标志物）较低。

背景：抗磷脂抗体综合征（APS）是一种获得性自身免疫性疾病，以反复发生静脉或动脉血栓和/或妊娠并发症为特征。最近，血栓性 APS 与中性粒细胞胞外捕获物（NET）形成增加有关，这表明 NET 与 APS 相关血栓的严重程度有关：我们对接受抗磷脂抗体检测的患者（990 例阴性，374 例阳性）进行了一项回顾性研究，以评估中性粒细胞活化状态（通过中性粒细胞反应指数（NEU-RI）估算）与抗磷脂抗体之间的关联：结果：我们没有观察到全球阳性和阴性患者的中性粒细胞反应指数值存在差异。然而，有趣的是，我们发现高滴度 IgM 与低 NEU-RI 值之间存在关联，这表明中性粒细胞活化程度较低：我们的数据与最近关于固相 aPL IgM 阳性的假定临床一致性的质疑一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Thrombosis and Thrombolysis 医学-外周血管病

CiteScore

9.20

自引率

0.00%

发文量

112

审稿时长

4-8 weeks

期刊介绍： The Journal of Thrombosis and Thrombolysis is a long-awaited resource for contemporary cardiologists, hematologists, vascular medicine specialists and clinician-scientists actively involved in treatment decisions and clinical investigation of thrombotic disorders involving the cardiovascular and cerebrovascular systems. The principal focus of the Journal centers on the pathobiology of thrombosis and vascular disorders and the use of anticoagulants, platelet antagonists, cell-based therapies and interventions in scientific investigation, clinical-translational research and patient care. The Journal will publish original work which emphasizes the interface between fundamental scientific principles and clinical investigation, stimulating an interdisciplinary and scholarly dialogue in thrombosis and vascular science. Published works will also define platforms for translational research, drug development, clinical trials and patient-directed applications. The Journal of Thrombosis and Thrombolysis'' integrated format will expand the reader''s knowledge base and provide important insights for both the investigation and direct clinical application of the most rapidly growing fields in medicine-thrombosis and vascular science.