Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism.

IF 2.8 Q3 GERIATRICS & GERONTOLOGY Annals of Geriatric Medicine and Research Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI:10.4235/agmr.24.0037
Ying Lin, Chen Lin, Jason Hong-Yi Chang, Dai-Lun Chiang, Feipei Lai, Chen-Ju Lin
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Abstract

Although neuropsychiatric manifestations are common in survivors of coronavirus disease 2019 (COVID-19), the pathophysiology is not yet elucidated. Here we describe the case of a geriatric inpatient who developed post-COVID depression with psychomotor retardation, anxiety, hopelessness, executive function problems, and suicidal ideations. The language problems and cognitive impairments coemerged with the motor problems. We propose a mechanism associated with problems in energy prediction and regulation in which the coronavirus infection, which causes neuroinflammation and viral activity in the nervous system, interferes with the reward pathway and sensory prediction process. Sigma-1 receptor agonists such as sertraline may regulate energy expenditure and, thus, be beneficial to the process. The treatment improvements in our patient included those in the autonomic nervous system, activity, and circadian rhythm.

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COVID-19 感染后的精神运动症状、认知障碍和自杀念头:病例报告和可能的异位机制。
虽然 2019 年冠状病毒病(COVID-19)幸存者中常见神经精神表现,但其病理生理学尚未阐明。在此,我们描述了一例老年住院病人的病例,该病人在 COVID 后出现抑郁,伴有精神运动迟滞、焦虑、绝望、执行功能问题和自杀意念。语言问题和认知障碍与运动问题同时出现。我们提出了一种与能量预测和调节问题相关的机制,即冠状病毒感染会导致神经系统的神经炎症和病毒活动,从而干扰奖赏通路和感觉预测过程。Sigma-1受体激动剂(如舍曲林)可调节能量消耗,因此对这一过程有益。我们的患者在治疗中得到的改善包括自律神经系统、活动和昼夜节律方面的改善。
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来源期刊
Annals of Geriatric Medicine and Research
Annals of Geriatric Medicine and Research GERIATRICS & GERONTOLOGY-
CiteScore
4.90
自引率
11.10%
发文量
35
审稿时长
4 weeks
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