Proteomic alterations in patients with atopic dermatitis.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS Expert Review of Proteomics Pub Date : 2024-05-01 Epub Date: 2024-05-22 DOI:10.1080/14789450.2024.2350938

Ashley Obi, Camille Rothenberg-Lausell, Sophia Levit, Ester Del Duca, Emma Guttman-Yassky

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Abstract

Introduction: Atopic Dermatitis (AD) is the most common inflammatory skin disease with a complex and multifactorial pathogenesis. The use of proteomics in understanding AD has yielded the discovery of novel biomarkers and may further expand therapeutic options.

Areas covered: This review summarizes the most recent proteomic studies and the methodologies used in AD. It describes novel biomarkers that may monitor disease course and therapeutic response. The review also highlights skin and blood biomarkers characterizing different AD phenotypes and differentiates AD from other inflammatory skin disorders. A literature search was conducted by querying Scopus, Google Scholar, Pubmed/Medline, and Clinicaltrials.gov up to June 2023.

Expert opinion: The integration of proteomics into research efforts in atopic dermatitis has broadened our understanding of the molecular profile of AD through the discovery of new biomarkers. In addition, proteomics may contribute to the development of targeted treatments ultimately improving personalized medicine. An increasing number of studies are utilizing proteomics to explore this heterogeneous disease.

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特应性皮炎患者的蛋白质组变化。

导言：特应性皮炎（AD）是最常见的炎症性皮肤病，其发病机制复杂且多因素。利用蛋白质组学了解特应性皮炎已发现了新的生物标志物，并可能进一步扩大治疗选择：本综述总结了最近的蛋白质组学研究以及在 AD 中使用的方法。它描述了可监测疾病进程和治疗反应的新型生物标志物。综述还强调了表征不同AD表型的皮肤和血液生物标记物，并将AD与其他炎症性皮肤病区分开来。通过查询Scopus、Google Scholar、Pubmed/Medline和Clinicaltrials.gov（截至2023年6月）进行了文献检索：将蛋白质组学纳入特应性皮炎的研究工作，通过发现新的生物标记物，拓宽了我们对特应性皮炎分子特征的了解。此外，蛋白质组学还有助于开发有针对性的治疗方法，最终改善个性化医疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.