Organocatalytic Fischer Indolization Using the 2,2′-Biphenol/ B(OH)3 System

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-17 DOI:10.1055/s-0043-1775363

Kenji Sugimoto, Yuji Matsuya, Yusei Wada, Fumino Kitamura

引用次数: 0

Abstract

An organocatalyzed Fischer indolization is established by combining 2,2′-biphenol (10 mol%) and B(OH)3 (30 mol%) as weak, readily available, and easy-to-handle acids. The inclusion of MgSO4, which efficiently scavenges NH3 (a possible acid catalyst poison), appears to be key to the success of this process. The corresponding indoles are obtained in yields of up to 91% using this method.y

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使用 2,2′-联苯酚/B(OH)3 系统的有机催化费舍尔吲哚化反应

通过将 2,2′-联苯酚 (10 mol%) 和 B(OH)3 (30 mol%) 作为弱酸、易得酸和易于处理的酸结合在一起，建立了一种有机催化的费歇尔吲哚化反应。MgSO4 能有效清除 NH3（一种可能的酸催化剂毒物），加入 MgSO4 似乎是这一工艺成功的关键。使用这种方法可以获得相应的吲哚，产率高达 91%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.