Exploring the role of ribosomal RNA modifications in cancer

IF 3.7 2区生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-05-17 DOI:10.1016/j.gde.2024.102204

Judith López , Sandra Blanco

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Abstract

Recent advances have highlighted the significant roles of post-transcriptional modifications in rRNA in various cancers. Evidence suggests that dysregulation of rRNA modifications acts as a common denominator in cancer development, with alterations in these modifications conferring competitive advantages to cancer cells. Specifically, rRNA modifications modulate protein synthesis and favor the specialized translation of oncogenic programs, thereby contributing to the formation of a protumorigenic proteome in cancer cells. These findings reveal a novel regulatory layer mediated by changes in the deposition of rRNA chemical modifications. Moreover, inhibition of these modifications in vitro and in preclinical studies demonstrates potential therapeutic applications. The recurrence of altered rRNA modification patterns across different types of cancer underscores their importance in cancer progression, proposing them as potential biomarkers and novel therapeutic targets. This review will highlight the latest insights into how post-transcriptional rRNA modifications contribute to cancer progression and summarize the main developments and ongoing challenges in this research area.

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探索核糖体 RNA 修饰在癌症中的作用。

最近的研究进展突显了 rRNA 转录后修饰在各种癌症中的重要作用。有证据表明，rRNA修饰失调是癌症发展过程中的一个共同点，这些修饰的改变为癌细胞带来了竞争优势。具体来说，rRNA 修饰会调节蛋白质合成，有利于致癌程序的专业化翻译，从而促进癌细胞中原致癌蛋白质组的形成。这些发现揭示了一个由 rRNA 化学修饰沉积变化介导的新型调节层。此外，在体外和临床前研究中抑制这些修饰具有潜在的治疗用途。rRNA 修饰模式的改变在不同类型的癌症中反复出现，这凸显了它们在癌症进展中的重要性，并将它们作为潜在的生物标志物和新的治疗靶点。本综述将重点介绍有关转录后 rRNA 修饰如何导致癌症进展的最新见解，并总结该研究领域的主要进展和当前面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)

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