{"title":"Features of the Solvation of Glycyl-l-alanine in Various Aqueous–Organic Mixtures at T = 298.15 K","authors":"Valeriy I. Smirnov*, ","doi":"10.1021/acs.jced.4c00136","DOIUrl":null,"url":null,"abstract":"<p >In the present work, an assessment of the processes of glycyl-<span>l</span>-alanine solvation is given when the nature of an aqueous–organic mixture changes. For this purpose, the enthalpies of the glycyl-<span>l</span>-alanine dissolution in aqueous solutions of ethanol, 1-propanol, 2-propanol, acetonitrile, 1,4-dioxane, acetone, and dimethyl sulfoxide were measured by isothermal calorimetry at <i>T</i> = 298.15 K. Corresponding enthalpies of solvation (Δ<sub>solv</sub><i>H</i>°) were determined by combining the obtained values (Δ<sub>sol</sub><i>H</i>°) with the standard enthalpies (Δ<sub>sub</sub><i>H</i>°) of glycyl-<span>l</span>-alanine sublimation. In addition, we derived the enthalpic coefficients of the pairwise interactions (<i>h</i><sub><i>xy</i></sub>) between glycyl-<span>L</span>-alanine and organic solvent molecules, as well as the transfer enthalpies (Δ<sub>tr</sub><i>H</i>°) from water in admixture with them. A comparative analysis of changes in the transfer enthalpies of glycyl-<span>l</span>-alanine, glycyl-glycine and glycyl-<span>l</span>-tyrosine from water to similar water–organic mixtures is presented. The modified Kamlet–Taft equation was used to quantify the contribution of some physicochemical properties of organic solvents (polarity/polarizability, cohesion energy density, basicity, and acidity) to the energy of intermolecular interactions of glycyl-<span>l</span>-alanine–cosolvent.</p>","PeriodicalId":42,"journal":{"name":"Journal of Chemical & Engineering Data","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical & Engineering Data","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jced.4c00136","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In the present work, an assessment of the processes of glycyl-l-alanine solvation is given when the nature of an aqueous–organic mixture changes. For this purpose, the enthalpies of the glycyl-l-alanine dissolution in aqueous solutions of ethanol, 1-propanol, 2-propanol, acetonitrile, 1,4-dioxane, acetone, and dimethyl sulfoxide were measured by isothermal calorimetry at T = 298.15 K. Corresponding enthalpies of solvation (ΔsolvH°) were determined by combining the obtained values (ΔsolH°) with the standard enthalpies (ΔsubH°) of glycyl-l-alanine sublimation. In addition, we derived the enthalpic coefficients of the pairwise interactions (hxy) between glycyl-L-alanine and organic solvent molecules, as well as the transfer enthalpies (ΔtrH°) from water in admixture with them. A comparative analysis of changes in the transfer enthalpies of glycyl-l-alanine, glycyl-glycine and glycyl-l-tyrosine from water to similar water–organic mixtures is presented. The modified Kamlet–Taft equation was used to quantify the contribution of some physicochemical properties of organic solvents (polarity/polarizability, cohesion energy density, basicity, and acidity) to the energy of intermolecular interactions of glycyl-l-alanine–cosolvent.
期刊介绍:
The Journal of Chemical & Engineering Data is a monthly journal devoted to the publication of data obtained from both experiment and computation, which are viewed as complementary. It is the only American Chemical Society journal primarily concerned with articles containing data on the phase behavior and the physical, thermodynamic, and transport properties of well-defined materials, including complex mixtures of known compositions. While environmental and biological samples are of interest, their compositions must be known and reproducible. As a result, adsorption on natural product materials does not generally fit within the scope of Journal of Chemical & Engineering Data.