Generalities on a delayed spatiotemporal host-pathogen infection model with distinct dispersal rates

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-05-16 DOI:10.1051/mmnp/2024008
Djilali salih
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Abstract

We propose a general model to investigate the effect of the distinct dispersal coefficient {for the} infected and susceptible hosts on the pathogen dynamics. The mathematical challenge lies in the fact that the investigated model is partially degenerate and the solution map is not compact. The spatial heterogeneity of the model parameters and the distinct diffusion coefficients induce infection in the low-risk regions. In fact, as infection dispersal increases, the reproduction of the pathogen particles decreases. The dynamics of the investigated model is governed by the value of the basic reproduction number $R_0$. {If $R_0\leq1$, then the} pathogen particles extinct, and for $R_0>1$ the pathogen particles persist, and we guarantees of the existence of at least one positive steady state. The asymptotic profile of the positive steady state is shown in the case when one or both diffusion coefficients for the host tends to zero or infinity.
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具有不同扩散率的延迟时空宿主-病原体感染模型的一般情况
我们提出了一个通用模型来研究{感染宿主和易感宿主的}不同扩散系数对病原体动态的影响。数学上的挑战在于所研究的模型是部分退化的,解图并不紧凑。模型参数的空间异质性和不同的扩散系数会诱发低风险区域的感染。事实上,随着感染扩散的增加,病原体粒子的繁殖会减少。所研究模型的动态受基本繁殖数 $R_0$ 值的支配。{如果 $R_0\leq1$,则}病原体粒子灭绝;如果 $R_0>1$,则病原体粒子持续存在,我们保证至少存在一个正稳态。当宿主的一个或两个扩散系数趋于零或无穷大时,正稳态的渐近曲线就会显示出来。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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