The Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA), Associated with Renal Compromise and Cutaneous Calcinosis: A Case Report and Literature Review
Cristian Betancur Henao, Juan Guillermo Rifaldo, Rafael Vicente-Pérez, M. C. Martínez-Ávila, Rodrigo Daza-Arnedo, Jorge Rico-Fontalvo
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引用次数: 0
Abstract
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 to provide a more precise syndromic characterization of clinical manifestations observed in patients exposed to adjuvant substances such as biopolymers and silicone, among others. The clinical spectrum of this entity is variable, ranging from local involvement to potentially fatal immune-mediated systemic involvement. The interest in ASIA has grown in recent years, reinforcing diagnostic criteria and deepening the understanding of its pathophysiological behavior. This case report highlights a distinct range of clinical symptoms, such as general symptoms, advanced-stage chronic kidney disease, persistent hypercalcemia with suppressed parathyroid hormone (PTH), bilateral nephrocalcinosis, cutaneous calcinosis, and the presence of positive autoantibodies, emphasizing the significance of understanding this condition.
佐剂诱发的自身免疫/炎症综合征（ASIA）于2011年首次提出，目的是对暴露于生物聚合物和硅酮等佐剂物质的患者的临床表现进行更精确的综合描述。这种疾病的临床表现多种多样，从局部受累到可能致命的免疫介导的全身受累，不一而足。近年来，人们对 ASIA 的兴趣与日俱增，不仅强化了诊断标准，还加深了对其病理生理行为的了解。本病例报告强调了一系列明显的临床症状，如全身症状、晚期慢性肾病、持续性高钙血症伴甲状旁腺激素（PTH）抑制、双侧肾钙化、皮肤钙化以及自身抗体阳性，强调了了解这种疾病的重要性。
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