{"title":"The Intra- and Intermolecular Friedel-Crafts Acylation of Amino Acid Derivatives in Stereo-Retarded Manner","authors":"Zetryana Puteri Tachrim, Makoto Hashimoto","doi":"10.2174/0113852728317263240510114622","DOIUrl":null,"url":null,"abstract":"\n\nThe Friedel-Crafts acylation of natural or unnatural amino acids in stereo-retarded manner is willing\nto prescribed here. Depending on its main skeleton, the typical intra- and intermolecular Friedel-Crafts reaction\nof amino acids can be differentiated. The unique amino acid’s general structure can contribute to the reaction\nbetween its carboxyl group and the side chain. Depending on the Friedel-Crafts reaction condition, the amino\nacid’s optical retention can be retarded. This perspective can contribute to the development of this one-century\nreaction in the field of organic chemistry.\n","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"21 9","pages":""},"PeriodicalIF":17.7000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0113852728317263240510114622","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The Friedel-Crafts acylation of natural or unnatural amino acids in stereo-retarded manner is willing
to prescribed here. Depending on its main skeleton, the typical intra- and intermolecular Friedel-Crafts reaction
of amino acids can be differentiated. The unique amino acid’s general structure can contribute to the reaction
between its carboxyl group and the side chain. Depending on the Friedel-Crafts reaction condition, the amino
acid’s optical retention can be retarded. This perspective can contribute to the development of this one-century
reaction in the field of organic chemistry.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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