Hydrophobic modification of polysaccharides and the construction and properties of their micelles: a review of applications in the field of biomedicine

IF 9.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Science China Chemistry Pub Date : 2024-05-13 DOI:10.1007/s11426-023-1916-5

Dayang Wang, Xiaohua Li, Huanchen Yao, Xin Liu, Yan Gao, Hailin Cong, Bing Yu, Youqing Shen

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Abstract

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific research. Polysaccharides have the characteristics of wide sources, excellent biocompatibility, and non-toxicity. In addition, there are multifunctional groups on the main chain of polysaccharides, which can be surface-modified or functionalized to have targeting ability through specific sugar parts. Amphiphilic polysaccharide micelles with good biocompatibility, degradability, high safety, easy structural modification, and special core-shell structure are regarded as ideal carriers for nanomedicines. Therefore, this review is focused on the hydrophobic modification designs of polysaccharides, the preparation methods and characteristics of micelles, and the applications of amphiphilic polysaccharide micelles in the field of biomedicine. It is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

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多糖的疏水改性及其胶束的构造和特性：生物医学领域应用综述

纳米药物传输技术在现代医学中发挥着重要作用，并在科学研究中显示出良好的治疗效果。多糖具有来源广泛、生物相容性好、无毒等特点。此外，多糖主链上有多功能基团，可通过特定的糖部分进行表面修饰或功能化，从而具有靶向能力。两亲多糖胶束具有良好的生物相容性、可降解性、高安全性、易结构修饰、特殊的核壳结构等特点，被认为是纳米药物的理想载体。因此，本综述主要介绍多糖的疏水修饰设计、胶束的制备方法和特点，以及两亲多糖胶束在生物医药领域的应用。希望能为多糖药物载体的设计提供一些思路和启发。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.