Chitosan-incorporated Bioceramic-based Nanomaterials for Localized Release of Therapeutics and Bone Regeneration: An Overview of Recent Advances and Progresses
{"title":"Chitosan-incorporated Bioceramic-based Nanomaterials for Localized Release of Therapeutics and Bone Regeneration: An Overview of Recent Advances and Progresses","authors":"Sajad Safarzadeh, M. R. Mozafari, S. M. Naghib","doi":"10.2174/0113852728304647240426201554","DOIUrl":null,"url":null,"abstract":"\n\nThe usage of nanoparticles in tissue engineering applications has increased significantly in the last\nseveral years. Functional tissues are developed by regulating cell proliferation, differentiation, and migration on\nnanostructured scaffolds containing cells. These scaffolds provide an environment that is more structurally supportive\nthan the microarchitecture of natural bone. Given its exceptional properties, such as its osteogenic potential,\nbiocompatibility, and biodegradability, chitosan is a good and promising biomaterial. Unfortunately,\nchitosan's low mechanical strength makes it unsuitable for load-bearing applications. By mixing chitosan with\nother biomaterials, this drawback might be mitigated. Bone tissue engineering uses both bioresorbable materials\nlike tricalcium phosphate and bioactive materials like hydroxyapatite and bioglass. Alumina and titanium are\nexamples of bioinert materials that are part of these bioceramics. When produced at nanoscale scales, these\nmaterials have a larger surface area and better cell adhesion. This review paper will go into great detail on the\nbioinert, bioresorbable, and bioactive nanoceramics-reinforced chitosan scaffolds for bone tissue engineering.\n","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0113852728304647240426201554","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The usage of nanoparticles in tissue engineering applications has increased significantly in the last
several years. Functional tissues are developed by regulating cell proliferation, differentiation, and migration on
nanostructured scaffolds containing cells. These scaffolds provide an environment that is more structurally supportive
than the microarchitecture of natural bone. Given its exceptional properties, such as its osteogenic potential,
biocompatibility, and biodegradability, chitosan is a good and promising biomaterial. Unfortunately,
chitosan's low mechanical strength makes it unsuitable for load-bearing applications. By mixing chitosan with
other biomaterials, this drawback might be mitigated. Bone tissue engineering uses both bioresorbable materials
like tricalcium phosphate and bioactive materials like hydroxyapatite and bioglass. Alumina and titanium are
examples of bioinert materials that are part of these bioceramics. When produced at nanoscale scales, these
materials have a larger surface area and better cell adhesion. This review paper will go into great detail on the
bioinert, bioresorbable, and bioactive nanoceramics-reinforced chitosan scaffolds for bone tissue engineering.
期刊介绍:
Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.