Association between plasma growth differentiation factor 15 levels and pre-eclampsia in China

Q1 Medicine Chronic Diseases and Translational Medicine Pub Date : 2024-05-12 DOI:10.1002/cdt3.126

Shuhong Xu, Yicheng Lu, Mengxin Yao, Zhuoqiao Yang, Yan Chen, Yaling Ding, Yue Xiao, Fei Liang, Jiani Qian, Jinchun Ma, Songliang Liu, Shilan Yan, Jieyun Yin, Qiuping Ma

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Abstract

Background

Growth differentiation factor-15 (GDF-15) is a stress response protein and is related to cardiovascular diseases (CVD). This study aimed to investigate the association between GDF-15 and pre-eclampsia (PE).

Method

The study involved 299 pregnant women, out of which 236 had normal pregnancies, while 63 participants had PE. Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits and then translated into multiple of median (MOM) to avoid the influence of gestational week at blood sampling. Logistic models were performed to estimate the association between GDF-15 MOM and PE, presenting as odd ratios (ORs) and 95% confidence intervals (CIs).

Results

MOM of GDF-15 in PE participants was higher compared with controls (1.588 vs. 1.000, p < 0.001). In the logistic model, pregnant women with higher MOM of GDF-15 (>1) had a 4.74-fold (95% CI = 2.23–10.08, p < 0.001) increased risk of PE, adjusted by age, preconceptional body mass index, gravidity, and parity.

Conclusions

These results demonstrated that higher levels of serum GDF-15 were associated with PE. GDF-15 may serve as a biomarker for diagnosing PE.

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血浆生长分化因子 15 水平与中国先兆子痫之间的关系

生长分化因子-15（GDF-15）是一种应激反应蛋白，与心血管疾病（CVD）有关。这项研究旨在调查 GDF-15 与先兆子痫（PE）之间的关系。研究涉及 299 名孕妇，其中 236 人正常怀孕，63 人患有先兆子痫。研究使用酶联免疫吸附试剂盒测定了母体血清中的GDF-15水平，然后将其转化为中位数的倍数（MOM），以避免采血时孕周的影响。经年龄、孕前体重指数、孕酮和胎次调整后，PE 参与者的 GDF-15 MOM 高于对照组（1.588 vs. 1.000，p 1），PE 风险增加 4.74 倍（95% CI = 2.23-10.08，p < 0.001）。GDF-15可作为诊断PE的生物标志物。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.

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