Pediatric discordant lymphoma with classic Hodgkin lymphoma in cervical lymph nodes and high-grade B-cell non-Hodgkin lymphoma in bone marrow: a case report from Pakistan

IF 1.2 Q4 ONCOLOGY ecancermedicalscience Pub Date : 2024-05-10 DOI:10.3332/ecancer.2024.1702
Namrita Rai, Zeenat Amna Azhar, Neelum Tahir Kheli, Fozia Lateef, Omer Javed, Muhammad Rafie Raza
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Abstract

Discordant lymphoma (DL) is an uncommon condition in which two or more histologically different types of lymphomas are present at distinct anatomical sites in the same patient. Here, we report a case of a pediatric patient under 10 years old presenting with symptoms of general sickness with cervical lymphadenopathy, abdominal distension and an abdominal mass. Upon conducting investigations, classic Hodgkin lymphoma (CHL) was detected in the cervical lymph nodes, and high-grade B-cell non-Hodgkin lymphoma was detected in the bone marrow and abdominal mass. The patient was therefore diagnosed with DL. The boy was initially diagnosed with CHL but proceeded to have aggressive disease progression, due to which further workup was done. In the past, literature reports have been published for adult cases of DL, and currently, research is being conducted to formulate treatment protocols for it. However pediatric cases of DL remain widely undis-cussed. Since we are dealing with a rare or widely underreported condition, we found it significant to elaborate on its clinical presentation, treatment plan, complications and prognosis.
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小儿不协调淋巴瘤,颈淋巴结为典型霍奇金淋巴瘤,骨髓为高级别 B 细胞非霍奇金淋巴瘤:来自巴基斯坦的病例报告
不协调淋巴瘤(DL)是一种不常见的病症,即在同一患者的不同解剖部位出现两种或两种以上组织学类型不同的淋巴瘤。在此,我们报告了一例 10 岁以下的儿童患者,其症状为全身不适,伴有颈部淋巴结肿大、腹胀和腹部肿块。经检查,在颈淋巴结中发现了典型的霍奇金淋巴瘤(CHL),在骨髓和腹部肿块中发现了高级别 B 细胞非霍奇金淋巴瘤。因此,患者被诊断为 DL。这名男孩最初被诊断为 CHL,但后来病情恶化,因此做了进一步检查。过去曾有关于成人 DL 病例的文献报道,目前正在进行相关研究,以制定治疗方案。然而,小儿 DL 病例仍未得到广泛讨论。由于我们面对的是一种罕见或广泛报道不足的病症,因此我们认为有必要详细阐述其临床表现、治疗方案、并发症和预后。
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来源期刊
CiteScore
3.80
自引率
5.60%
发文量
138
审稿时长
27 weeks
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