Unveiling the potential of Satureja calamintha nepeta: A study on its phytochemical composition and antibacterial activity

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-10 DOI:10.1002/vjch.202300174

Mouhcine Hayani, Tariq Benabbouha, Wafaa Nachit, Said Byadi, Khalil Chefira, Aziz Aboulmouhajir, A. Tounsi, T. Zair

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Abstract

Satureja calamintha nepeta is a plant native to northwestern Morocco. The purpose of this investigation is to identify the chemical composition and evaluate the antibacterial of the essential oil extracted from this plant. Firstly, a quality inspection of the plant was carried out to quantify its level of metals, especially the heavier ones, using the ICP technique. Gas chromatography/mass spectrometry was used to characterize the chemical composition of essential oil. The chromatogram analysis shows the presence of 27 compounds, that is, 99.2% of the essential oil, with 1,8‐cineole (34.34%) and cis‐pinocamphone (11.87%) being the most significant. The antibacterial effectiveness of the essential oil was tested using the disc diffusion method against 6 gram‐positive and gram‐negative pathogens. The essential oil shows strong activity against Escherichia coli and Escherichia vekanda strains, with an MIC value of about 2.80 µg/mL. The authors were benefited from the modeling technique to better understand the antibacterial activity.

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揭示 Satureja calamintha nepeta 的潜力：关于其植物化学成分和抗菌活性的研究

Satureja calamintha nepeta 是一种原产于摩洛哥西北部的植物。这项研究的目的是确定从这种植物中提取的精油的化学成分并评估其抗菌性。首先，利用 ICP 技术对植物进行了质量检测，以量化其中的金属含量，尤其是重金属含量。气相色谱/质谱法用于确定精油化学成分的特征。色谱分析显示，精油中含有 27 种化合物，占精油总量的 99.2%，其中以 1,8-蒎烯（34.34%）和顺式蒎烷（11.87%）的含量最高。精油的抗菌效果采用了盘扩散法对 6 种革兰氏阳性和革兰氏阴性病原体进行了测试。精油对大肠杆菌和维康达大肠杆菌菌株具有很强的活性，其 MIC 值约为 2.80 µg/mL。作者通过建模技术更好地了解了其抗菌活性。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.