Combinatorial entropy determines the early stages of nucleation

IF 1.7 4区 化学 Bulletin of the Korean Chemical Society Pub Date : 2024-05-09 DOI:10.1002/bkcs.12849
Da-Hyun Koo, Ho Jun Park, Jeong-Mo Choi
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Abstract

Biomolecular phase separation, a complex phenomenon within living systems, has garnered significant interest due to its diverse roles in cellular organization and function. Despite its importance, studying phase separation dynamics experimentally, particularly in the early stages, poses challenges. Our study investigates the dynamics of biomolecular phase separation using a graph-based simulation module, particularly emphasizing its early stages. Through a simplified model, we dissect the influences of various factors on collective behavior, highlighting the crucial role of combinatorial entropy in percolation dynamics. This study offers valuable insights into the fundamental principles governing biomolecular phase separation, with implications for understanding cellular processes and disease mechanisms.

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组合熵决定成核的早期阶段
生物分子相分离是生命系统中的一种复杂现象,由于其在细胞组织和功能中的多种作用,已引起人们的极大兴趣。尽管生物分子相分离现象非常重要,但实验研究相分离动力学,尤其是早期阶段的相分离动力学研究却面临着挑战。我们的研究利用基于图的模拟模块研究了生物分子相分离的动力学,尤其强调其早期阶段。通过简化模型,我们剖析了各种因素对集体行为的影响,强调了组合熵在渗流动力学中的关键作用。这项研究为了解生物分子相分离的基本原理提供了宝贵的见解,对理解细胞过程和疾病机制具有重要意义。
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来源期刊
Bulletin of the Korean Chemical Society
Bulletin of the Korean Chemical Society Chemistry-General Chemistry
自引率
23.50%
发文量
182
期刊介绍: The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
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