Carbapenem-Resistant Klebsiella pneumoniae Bacteremia: Counterbalance between the Endemic Load and the Infection Control Program in a Hospital

Q4 Medicine Acta Microbiologica Hellenica Pub Date : 2024-05-08 DOI:10.3390/amh69020009
Amalia Papanikolopoulou, Louisa Vini, Athina Stoupis, Dimitra Kalimeri, Anastasia Pangalis, G. Chronopoulou, N. Pantazis, Panagiotis Gargalianos-Kakolyris, M. Kantzanou
{"title":"Carbapenem-Resistant Klebsiella pneumoniae Bacteremia: Counterbalance between the Endemic Load and the Infection Control Program in a Hospital","authors":"Amalia Papanikolopoulou, Louisa Vini, Athina Stoupis, Dimitra Kalimeri, Anastasia Pangalis, G. Chronopoulou, N. Pantazis, Panagiotis Gargalianos-Kakolyris, M. Kantzanou","doi":"10.3390/amh69020009","DOIUrl":null,"url":null,"abstract":"Carbapenem-resistant Klebsiella pneumoniae (CRKP) remains a significant public health threat, given the associated increased healthcare burden and mortality rate. The objective of the current study was to investigate the association between the incidence of CRKP bacteremia, antibiotic consumption, and infection control measures in a tertiary-care hospital spanning the years 2013–2018. The analyzed indices included the incidence of CRKP bacteremia, antibiotic consumption, the use of hand hygiene solutions, and isolation rates of multidrug-resistant (MDR) carriers. In the total hospital, the incidence of CRKP bacteremia exhibited an absolute decrease during the study period, although this decrease did not reach statistical significance. Antibiotics used to treat CRKP infections, including carbapenems, colistin, tigecycline, and fosfomycin, as well as all classes of antibiotics, correlated positively with an increased incidence of CRKP bacteremia. On the contrary, increased use of scrub disinfectant solutions correlated negatively with a decreased incidence of CRKP bacteremia (IRR: 0.74, 95%CI: 0.59–0.93, p-value: 0.008) in the Adults ICU. Additionally, increased isolation rates of MDR carrier patients correlated negatively with a decreased incidence of CRKP bacteremia (IRR: 0.35, 95%CI: 0.13–0.97, p-value: 0.044). In conclusion, the implementation of multimodal infection control measures in our hospital contributed to the containment of CRKP, particularly in specific hospital sectors. However, the study suggests the need for additional strategies to overcome the endemic plateau.","PeriodicalId":34903,"journal":{"name":"Acta Microbiologica Hellenica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Microbiologica Hellenica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/amh69020009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) remains a significant public health threat, given the associated increased healthcare burden and mortality rate. The objective of the current study was to investigate the association between the incidence of CRKP bacteremia, antibiotic consumption, and infection control measures in a tertiary-care hospital spanning the years 2013–2018. The analyzed indices included the incidence of CRKP bacteremia, antibiotic consumption, the use of hand hygiene solutions, and isolation rates of multidrug-resistant (MDR) carriers. In the total hospital, the incidence of CRKP bacteremia exhibited an absolute decrease during the study period, although this decrease did not reach statistical significance. Antibiotics used to treat CRKP infections, including carbapenems, colistin, tigecycline, and fosfomycin, as well as all classes of antibiotics, correlated positively with an increased incidence of CRKP bacteremia. On the contrary, increased use of scrub disinfectant solutions correlated negatively with a decreased incidence of CRKP bacteremia (IRR: 0.74, 95%CI: 0.59–0.93, p-value: 0.008) in the Adults ICU. Additionally, increased isolation rates of MDR carrier patients correlated negatively with a decreased incidence of CRKP bacteremia (IRR: 0.35, 95%CI: 0.13–0.97, p-value: 0.044). In conclusion, the implementation of multimodal infection control measures in our hospital contributed to the containment of CRKP, particularly in specific hospital sectors. However, the study suggests the need for additional strategies to overcome the endemic plateau.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
耐碳青霉烯类肺炎克雷伯菌菌血症:一家医院的流行病学负荷与感染控制计划之间的平衡
耐碳青霉烯类肺炎克雷伯氏菌(CRKP)会增加医疗负担和死亡率,因此仍是一个重大的公共卫生威胁。本研究旨在调查一家三级甲等医院 2013-2018 年间 CRKP 菌血症发病率、抗生素用量和感染控制措施之间的关联。分析指标包括CRKP菌血症的发生率、抗生素消耗量、手部卫生溶液的使用以及耐多药(MDR)带菌者的分离率。在整个医院中,CRKP菌血症的发生率在研究期间出现了绝对下降,尽管这种下降没有达到统计学意义。用于治疗 CRKP 感染的抗生素,包括碳青霉烯类、可乐定、替加环素和磷霉素,以及所有类别的抗生素,都与 CRKP 菌血症发生率的增加呈正相关。相反,在成人重症监护病房,擦洗消毒液使用量的增加与 CRKP 菌血症发生率的降低呈负相关(IRR:0.74,95%CI:0.59-0.93,P 值:0.008)。此外,MDR 携带者患者隔离率的提高与 CRKP 菌血症发生率的降低呈负相关(IRR:0.35,95%CI:0.13-0.97,P 值:0.044)。总之,我院实施的多模式感染控制措施有助于遏制 CRKP,尤其是在医院的特定部门。然而,本研究表明需要采取更多的策略来克服地方病高发的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Acta Microbiologica Hellenica
Acta Microbiologica Hellenica Medicine-Microbiology (medical)
CiteScore
0.20
自引率
0.00%
发文量
6
期刊最新文献
Exploring Bacteriophage Applications in Medicine and Beyond Assembly and Annotation of the Complete Genome Sequence of the Paenibacillus Bacteriophage phJNUCC32 Combating Malaria with Vaccines: Insights from the One Health Framework The Value of a “One Health” Approach—The Updated Scope of Acta Microbiologica Hellenica Mathematical Modelling of Gonorrhoea Spread in Northern Ireland between 2012 and 2022
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1