A clinical case of a continuous course of ulcerative with extra-intestinal manifestations

G. Bikbavova, V. A. Livzan, V. Akhmedov, T. V. Tretyakova, V. A. Voyat, L. I. Telyatnikova
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Abstract

Ulcerative colitis (UC) is one of the most serious and poor-studied problems of modern gastroenterology. This nosology is a diffuse inflammation of the intestinal mucosa, limited to the colon with a predominant lesion of the rectum and sigmoid colon. Due to the progressive nature of the disease, patients require lifelong drug therapy and monitoring. Extra-intestinal manifestations are often found in patients with UC and represent a complex problem that requires the close attention of specialists and the appointment of modern pathogenetically-based treatment, including genetically engineered biological drugs. This clinical observation reflects the importance of early diagnosis of UC with extra-intestinal manifestations – primary sclerosing cholangitis and arthropathy, as well as the effectiveness of treatment with ustekinumab.
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一个溃疡病持续病程并伴有肠外表现的临床病例
溃疡性结肠炎(UC)是现代肠胃病学中最严重、研究最不深入的问题之一。溃疡性结肠炎是一种肠粘膜弥漫性炎症,局限于结肠,以直肠和乙状结肠为主。由于该病具有进展性,患者需要终生接受药物治疗和监测。UC 患者经常会出现肠外表现,这是一个复杂的问题,需要专科医生密切关注,并采用基于病理的现代治疗方法,包括基因工程生物药物。这一临床观察结果反映了早期诊断伴有肠道外表现--原发性硬化性胆管炎和关节病--的 UC 的重要性,以及使用乌斯特库单抗治疗的有效性。
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