One-pot and Three Component Coupling Synthesis of Novel para-((Benzothiazolylamino)(aryl/heteroaryl)methyl)-phenols and its Corresponding O-Tosylates under Catalyst- and Solvent-Free Conditions
Mohammed Bakr Hawsawi, Alluhaibi S. Mustafa, Narasimhulu Gandhamsetty
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引用次数: 0
Abstract
A catalyst- and solvent-free procedure has been developed for the synthesis of para-(( Benzothiazolylamino)(aryl/heteroaryl)methyl)-functionalized phenols and its O-tosylates via one-pot three component coupling reaction of thymol or carvacrol, aryl/heteroaryl aldehydes, and 2-aminobenzothiazoles with high selectivity. The present amino methylation process is convenient to perform even on large scale with a broad scope. The products were likely formed through the initial para-attack of thymol on aldehydes to generate para-quinone methide intermediate and subsequent 1,6-Aza-Michael addition of 2-aminobenzothiazoles on in-situ generated para-quinone methide intermediate.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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