Prevalence of multidrug resistance pathogens in dermatology: A retrospective study in Romania, 2018-2022

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-06 DOI:10.29333/ejgm/14572

A. Iancu, N. Maftei, C. Dumitru, Liliana Baroiu, Gabriela Gurău, A. Elisei, Claudia Simona Stefan, A. Tatu, Alexandru-Florin Iancu, M. Arbune

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Abstract

Antimicrobial resistance (AMR) is now a major challenge to clinicians in treating patients. The purpose of our study was to determine the incidence of multidrug resistant (MDR) strains and antibiotic resistance profile in department of dermatology-venereology from a Romanian infectious disease’s hospital. We analyzed 1,152 bacterial strains, we obtained 34.5% MDR strains, identifying the following species: staphylococcus aureus 43.6%, enterococcus spp 16.7%, escherichia coli 31.0%, proteus spp 27.1%, klebsiella spp. 22.4%, pseudomonas spp. 34.8%. Overall, the rate of methicillin-resistant staphylococcus aureus was 76.1%; extended spectrum beta-lactamase production was 46.1% for escherichia coli and 66.0% for klebsiella pneumoniae; carbapenems-resistance was 51.0% for pseudomonas aeruginosa. All strains of E. coli and klebsiella were sensitive to meropenem. Our results confirm the high level of AMR, and continuous monitoring is essential for updating the local diagnostic and treatment protocols for dermatological infections.

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皮肤科多重耐药病原体的流行情况：2018-2022年罗马尼亚回顾性研究

抗菌药耐药性（AMR）是临床医生治疗病人时面临的一大挑战。我们的研究旨在确定罗马尼亚一家传染病医院皮肤科-耳鼻喉科的耐多药（MDR）菌株发生率和抗生素耐药性概况。我们对 1,152 株细菌进行了分析，发现 34.5% 的耐多药菌株属于以下菌种：金黄色葡萄球菌 43.6%、肠球菌 16.7%、大肠埃希菌 31.0%、变形杆菌 27.1%、克雷伯氏菌 22.4%、假单胞菌 34.8%。总体而言，耐甲氧西林金黄色葡萄球菌的比例为 76.1%；大肠埃希菌和肺炎克雷伯菌产生广谱β-内酰胺酶的比例分别为 46.1%和 66.0%；铜绿假单胞菌产生碳青霉烯类耐药性的比例为 51.0%。所有的大肠杆菌和克雷伯氏菌都对美罗培南敏感。我们的研究结果证实，AMR 的水平很高，持续监测对于更新当地皮肤感染的诊断和治疗方案至关重要。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.