Jian-Liang Ye, Li-Ning Chen, Zhao-Ke Jin, Pei-Qiang Huang
{"title":"Tf2O-mediated Mild Synthesis of 6H-Chromeno[4,3-b]quinolines","authors":"Jian-Liang Ye, Li-Ning Chen, Zhao-Ke Jin, Pei-Qiang Huang","doi":"10.24820/ark.5550190.p012.191","DOIUrl":null,"url":null,"abstract":"A facile and versatile synthesis of 6 H -chromeno[4,3-b ]quinolines has been achieved through triflic anhydride/2-fluoropyridine (Tf 2 O/2-F-Pyr)-promoting domino intramolecular cycloaddition reactions of salicylic-acid-derived N -phenyl- ortho -propynyloxy benzamides under mild, and metal-free conditions. This protocol is efficient, scalable, and well compatible with a broad scope of substrates bearing halogens, trifluoromethyl","PeriodicalId":0,"journal":{"name":"","volume":"25 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.24820/ark.5550190.p012.191","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A facile and versatile synthesis of 6 H -chromeno[4,3-b ]quinolines has been achieved through triflic anhydride/2-fluoropyridine (Tf 2 O/2-F-Pyr)-promoting domino intramolecular cycloaddition reactions of salicylic-acid-derived N -phenyl- ortho -propynyloxy benzamides under mild, and metal-free conditions. This protocol is efficient, scalable, and well compatible with a broad scope of substrates bearing halogens, trifluoromethyl