Tf2O-mediated Mild Synthesis of 6H-Chromeno[4,3-b]quinolines

Pub Date : 2024-05-02 DOI:10.24820/ark.5550190.p012.191
Jian-Liang Ye, Li-Ning Chen, Zhao-Ke Jin, Pei-Qiang Huang
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Abstract

A facile and versatile synthesis of 6 H -chromeno[4,3-b ]quinolines has been achieved through triflic anhydride/2-fluoropyridine (Tf 2 O/2-F-Pyr)-promoting domino intramolecular cycloaddition reactions of salicylic-acid-derived N -phenyl- ortho -propynyloxy benzamides under mild, and metal-free conditions. This protocol is efficient, scalable, and well compatible with a broad scope of substrates bearing halogens, trifluoromethyl
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Tf2O 介导的 6H-色烯并[4,3-b]喹啉的温和合成
在温和、无金属的条件下,通过三酸酐/2-氟吡啶(Tf 2 O/2-F-Pyr)促进水杨酸衍生的 N-苯基-原-丙炔氧基苯甲酰胺的多米诺分子内环加成反应,实现了 6 H-色烯并[4,3-b]喹啉的简便、多功能合成。该方案高效、可扩展,并与多种含卤素、三氟甲基和三氟乙酰基的底物兼容。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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