Physical, antimicrobial, and release profiles of orthodontic adhesives modified with chlorhexidine and cetylpyridinium chloride

Pub Date : 2024-05-01 DOI:10.1166/mex.2024.2652

A. Alshehri, N. Albar

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Abstract

The aim of the present study was to evaluate the properties (physical, antimicrobial, and release profiles) by using modified orthodontic adhesives on extracted teeth. Three primers, Transbond (Tx), Transbond-Chlorhexidine (Tx-CHx), and Transbond-Cetylpyridinium chloride (Tx-CTP), containing antibacterial agents CHx and CTP, were tested against Streptococcus mutans (Sm) in planktonic and biofilm phases. Their antimicrobial activities (biofilm and growth assays), affected by water aging, were analyzed along with shear bond strength and mode of fracture after bonding brackets onto bovine incisors. Tx-CHx demonstrated superior antimicrobial activity against in both planktonic and biofilm states, completely inhibiting their growth and biofilm formation. This effectiveness persisted after thermocycling. Conversely, Tx-CTP showed a positive outcome against microbial activity compared to Tx. Shear bond strength (SBS) (Tx–11.21±1.72; Tx-CTP–12.48±2.50; Tx-CHx–11.57±2.28) and bond failure interface showed no significant differences among the three primers. Adding CHx and CTP to an orthodontic primer could potentially safeguard enamel from demineralization without negatively impacting its structural characteristics.

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用氯己定和氯化十六烷基吡啶改性的正畸粘合剂的物理、抗菌和释放特征

本研究的目的是评估在拔出的牙齿上使用改良正畸粘合剂的特性（物理、抗菌和释放特性）。对含有抗菌剂 CHx 和 CTP 的 Transbond (Tx)、Transbond-Chlorhexidine (Tx-CHx) 和 Transbond-Cetylpyridinium chloride (Tx-CTP) 三种引物进行了浮游和生物膜阶段的抗变异链球菌（Sm）测试。分析了它们的抗菌活性（生物膜和生长试验）受水老化的影响，以及将托架粘结到牛门牙上后的剪切粘结强度和断裂模式。Tx-CHx 在浮游生物和生物膜状态下都表现出卓越的抗菌活性，完全抑制了它们的生长和生物膜的形成。这种效果在热循环后依然存在。相反，与 Tx 相比，Tx-CTP 对微生物活性的抑制效果更好。三种引物的剪切粘接强度（SBS）（Tx-11.21±1.72；Tx-CTP-12.48±2.50；Tx-CHx-11.57±2.28）和粘接破坏界面无显著差异。在正畸底漆中添加 CHx 和 CTP 有可能防止釉质脱矿，而不会对其结构特性产生负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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