Assessing the Role of Asthma on the Relationship between Neurodevelopmental Disabilities and Adverse Birth Outcomes

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Pediatric neurology Pub Date : 2024-05-03 DOI:10.1016/j.pediatrneurol.2024.04.023

Omobola Oluwafemi MPH , Sneha Manoharan BS , Luyu Xie PharmD, PhD , George Pro PhD , Rikinkumar S. Patel MD , George L. Delclos MD, PhD , Andrew Gelfand MD , Sarah E. Messiah PhD , David S. Lopez DrPH , Jenil Patel MBBS, MPH, PhD

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Abstract

Background

Investigating asthma as an effect modifier between adverse birth outcomes and neurodevelopmental disabilities (NDDs) across different races is crucial for tailored interventions and understanding variable susceptibility among diverse populations.

Methods

Data were collected through the National Survey of Children’s Health. This cross-sectional study included 131,774 children aged 0 to 17 years. Study exposures comprised adverse birth outcomes including preterm birth and low birth weight. Weighted prevalence estimates and odds ratios with 95% confidence intervals (CIs) among children with and without adverse birth outcomes were calculated for NDDs including attention-deficit/hyperactivity disorder, autism spectrum disorder, cerebral palsy, seizure, and several others including behavior problems. Adjusted odds ratios were stratified by asthma status and separate interactions were assessed for each outcome.

Results

Of 131,774 participants, 10,227 were born low birth weight (9.12%; 95% CI: 8.77% to 9.49%), 14,058 were born preterm (11.35%; 95% CI: 10.94% to 11.76%), and 16,166 participants had asthma (11.97%; 95% CI: 11.58% to 12.37%). There were 68,100 males (51.11%), 63,674 females (48.89%), 102,061 non-Hispanic Whites (NHW) (66.92%), 8,672 non-Hispanic Blacks (NHB) (13.97%), and 21,041 participants (19.11%) categorized as other. NHB children with adverse birth outcomes had higher prevalence of several NDDs compared to NHW children.

Conclusions

Asthma was not shown to be an effect modifier of the association between adverse birth outcomes and NDDs. Nevertheless, these results suggest that NDDs are more prevalent within US children with adverse birth outcomes, with higher rates among NHB compared to NHW children. These findings support screening for NDDs in pediatric health care settings among patients with adverse birth outcomes, particularly among those from ethnic minority backgrounds.

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评估哮喘对神经发育障碍和不良出生结果之间关系的作用

背景调查哮喘作为不同种族的不良出生结果和神经发育障碍（NDDs）之间的效应调节因子，对于量身定制干预措施和了解不同人群的易感性至关重要。这项横断面研究包括 131,774 名 0 至 17 岁的儿童。研究暴露包括早产和出生体重不足等不良出生结果。针对包括注意力缺陷/多动障碍、自闭症谱系障碍、大脑性麻痹、癫痫以及包括行为问题在内的其他几种非传染性疾病，计算了有和没有不良出生结果的儿童的加权患病率估计值和几率比，并得出了 95% 的置信区间 (CI)。结果在 131,774 名参与者中，10,227 人出生时体重不足（9.12%；95% CI：8.77% 至 9.49%），14,058 人早产（11.35%；95% CI：10.94% 至 11.76%），16,166 人患有哮喘（11.97%；95% CI：11.58% 至 12.37%）。男性有 68100 人（51.11%），女性有 63674 人（48.89%），非西班牙裔白人有 102061 人（66.92%），非西班牙裔黑人有 8672 人（13.97%），其他类别有 21041 人（19.11%）。结论哮喘未被证明是不良出生结果与 NDDs 之间关联的效应调节因子。尽管如此，这些结果表明，NDDs 在出生时有不良后果的美国儿童中更为普遍，与 NHW 儿童相比，NHB 儿童中的 NDDs 患病率更高。这些研究结果支持在儿科医疗机构中对有不良出生结果的患者，尤其是少数民族背景的患者进行 NDD 筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.