Aberrant baseline cytokine profile in patients with newly diagnosed acquired aplastic anaemia correlates with disease severity and the treatment response

IF 2.1 4区医学 Q3 HEMATOLOGY Blood Cells Molecules and Diseases Pub Date : 2024-05-16 DOI:10.1016/j.bcmd.2024.102857

Rahul Vatsayan , Ankur Jain , Aditya Jandial , Parveen Bose , Man Updesh Singh Sachdeva , Neelam Varma , Arihant Jain , Gaurav Prakash , Alka Khadwal , Pankaj Malhotra

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Abstract

Background

Immune dysregulation is crucial in the pathogenesis of acquired aplastic anaemia (aAA). There is paucity of data regarding correlation of baseline cytokine profile with treatment response in aAA.

Objective

Present prospective case-control study aimed to correlate the baseline cytokines in patients with aAA with the treatment response.

Methods

Fifty-one patients with newly-diagnosed aAA > 13 years of either sex were enrolled over 1.5 years. Twenty age-and sex-matched healthy controls (HC) were also included. The cytokine profile (IL-2, 4, 6, 8, 10, 17, IFN-γ and TNF-α) in the peripheral blood plasma of aAA patients was performed at the baseline using cytometric bead analysis. The cytokine levels were compared with HC and correlated with response to immunosuppressive therapy (IST) at 3-months.

Results

The median age of cases was 29 years (range,13–74). The cases had higher mean levels of IL2 (p = 0.326), IL4 (p = 0.038), IL6 (p = 0.000), IL10 (p = 0.002), TNF-α (p = 0.302), IFN-γ (p = 0.569) and IL-17 (p = 0.284) than the HC. The baseline levels of all the cytokines were higher (statistically non-significant) among responders (n = 13) than the non-responders (n = 14) to IST.

Conclusions

Baseline cytokine profile in patients with aAA might predict response to the IST. Larger studies are needed to validate our results.

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新诊断的获得性再生障碍性贫血患者的细胞因子基线谱异常与疾病严重程度和治疗反应有关

背景免疫失调在获得性再生障碍性贫血（aAA）的发病机制中至关重要。本前瞻性病例对照研究旨在将获得性再生障碍性贫血（AAA）患者的基线细胞因子与治疗反应相关联。此外还纳入了 20 名年龄和性别匹配的健康对照组（HC）。在基线时，使用细胞测量珠分析法对 aAA 患者外周血血浆中的细胞因子（IL-2、4、6、8、10、17、IFN-γ 和 TNF-α）进行了分析。结果病例的中位年龄为 29 岁（13-74 岁）。病例的 IL2 (p = 0.326)、IL4 (p = 0.038)、IL6 (p = 0.000)、IL10 (p = 0.002)、TNF-α (p = 0.302)、IFN-γ (p = 0.569) 和 IL-17 (p = 0.284) 的平均水平高于 HC。所有细胞因子的基线水平在对 IST 有反应者（n = 13）中均高于无反应者（n = 14）（无统计学意义）。需要更大规模的研究来验证我们的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Cells Molecules and Diseases 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

14 days

期刊介绍： Blood Cells, Molecules & Diseases emphasizes not only blood cells, but also covers the molecular basis of hematologic disease and studies of the diseases themselves. This is an invaluable resource to all those interested in the study of hematology, cell biology, immunology, and human genetics.