Stem cell therapy as a promising approach for ischemic stroke treatment

Q2 Agricultural and Biological Sciences Current Research in Pharmacology and Drug Discovery Pub Date : 2024-01-01 DOI:10.1016/j.crphar.2024.100183

Sahar Yaqubi, Mohammad Karimian

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Abstract

Ischemia as the most common type of stroke is the main cause of death and disability in the world. However, there are few therapeutic approaches to treat ischemic stroke. The common approach to the treatment of ischemia includes surgery-cum-chemical drugs. Surgery and chemical drugs are used to remove blood clots to prevent the deterioration of the nervous system. Given the surgical hazards and the challenges associated with chemical drugs, these cannot be considered safe approaches to the treatment of brain ischemia. Besides surgery-cum-chemical drugs, different types of stem cells including mesenchymal stem cells and neurological stem cells have been considered to treat ischemic stroke. Therapeutic approaches utilizing stem cells to treat strokes are promising because of their neuroprotective and regenerative benefits. However, the mechanisms by which the transplanted stem cells perform their precisely actions are unknown. The purpose of this study is to critically review stem cell-based therapeutic approaches for ischemia along with related challenges.

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干细胞疗法是治疗缺血性中风的有效方法

缺血性中风是最常见的中风类型，也是世界上导致死亡和残疾的主要原因。然而，治疗缺血性中风的方法很少。治疗缺血性中风的常用方法包括手术和化学药物。手术和化学药物用于清除血凝块，防止神经系统恶化。鉴于手术的危险性和化学药物带来的挑战，这些都不能被视为治疗脑缺血的安全方法。除了手术和化学药物外，不同类型的干细胞（包括间充质干细胞和神经干细胞）也被用来治疗缺血性中风。利用干细胞治疗中风的方法很有前景，因为干细胞具有神经保护和再生功能。然而，移植干细胞发挥精确作用的机制尚不清楚。本研究的目的是对基于干细胞的缺血治疗方法及相关挑战进行批判性回顾。

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