Multiscale brain age prediction reveals region-specific accelerated brain aging in Parkinson's disease

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY Neurobiology of Aging Pub Date : 2024-05-14 DOI:10.1016/j.neurobiolaging.2024.05.003

Yueh-Sheng Chen , Chen-Yuan Kuo , Cheng-Hsien Lu , Yuan-Wei Wang , Kun-Hsien Chou , Wei-Che Lin

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Abstract

Brain biological age, which measures the aging process in the brain using neuroimaging data, has been used to assess advanced brain aging in neurodegenerative diseases, including Parkinson disease (PD). However, assuming that whole brain degeneration is uniform may not be sufficient for assessing the complex neurodegenerative processes in PD. In this study we constructed a multiscale brain age prediction models based on structural MRI of 1240 healthy participants. To assess the brain aging patterns using the brain age prediction model, 93 PD patients and 91 healthy controls matching for sex and age were included. We found increased global and regional brain age in PD patients. The advanced aging regions were predominantly noted in the frontal and temporal cortices, limbic system, basal ganglia, thalamus, and cerebellum. Furthermore, region-level rather than global brain age in PD patients was associated with disease severity. Our multiscale brain age prediction model could aid in the development of objective image-based biomarkers to detect advanced brain aging in neurodegenerative diseases.

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多尺度脑年龄预测揭示帕金森病特定区域加速脑衰老的原因

脑生物年龄利用神经影像学数据测量大脑的衰老过程，已被用于评估包括帕金森病（PD）在内的神经退行性疾病的大脑晚期衰老。然而，假设整个大脑的退化是一致的，可能不足以评估帕金森病复杂的神经退行性过程。在这项研究中，我们基于1240名健康参与者的结构性核磁共振成像构建了一个多尺度脑年龄预测模型。为了使用脑年龄预测模型评估脑衰老模式，我们纳入了 93 名帕金森病患者和 91 名性别和年龄匹配的健康对照者。我们发现帕金森氏症患者的整体和区域脑龄均有所增加。高龄化区域主要分布在额叶和颞叶皮层、边缘系统、基底节、丘脑和小脑。此外，与疾病严重程度相关的是帕金森病患者的区域年龄而非整体脑年龄。我们的多尺度脑年龄预测模型有助于开发基于图像的客观生物标志物，以检测神经退行性疾病的晚期脑衰老。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.