Zinc transporters expression profile in professional handball players supplemented with zinc

IF 3.6 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Trace Elements in Medicine and Biology Pub Date : 2024-05-16 DOI:10.1016/j.jtemb.2024.127473
Jorge Molina-López , Daniela Florea , Yenifer Gamarra-Morales , Lourdes Herrera-Quintana , Héctor Vázquez-Lorente , Christer Hogstrand , Elena Planells
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Abstract

Introduction

Zinc (Zn) deficiency has been described not only on general human health but also within the sports context –as negatively affecting performance–. Thus, Zn status assessment is of great interest for athletes, especially in order to correct deficiency states of this mineral.

Objective

The overall objective of this work was to assess Zn status in professional handball players during the competitive period (through plasma levels, dietary intake and gene expression of the Zn transporters), as well as to determine the effect of Zn supplementation.

Methods

A total of twenty-two participants were recruited, –twelve belonged to the Control Group (CG) and ten male handball players comprised the experimental group (ATH-G)–, being monitored over a 2-month period with 2 evaluation moments: baseline (i.e., initial conditions) and follow-up (i.e., after 8 weeks of training and competition). Zn intake, plasma Zn levels, and gene expression of Zn transporters were obtained.

Results

Plasma Zn levels were higher in ATH-G than in CG at the end of Zn intervention (p ≤ 0.010). Moreover, differences in the gene expression profile of Zn transporters were observed in ATH-G –with the down-regulation of several Zn transporters–, compared to the CG at baseline (p ≤ 0.05). Likewise, differences in the Zn transporters expression were observed in ATH-G at 8 weeks (all, p ≤ 0.001) –with ZnT2, ZnT5, ZIP3, ZIP5, ZIP11, ZIP13 and ZIP14 transporters being up-regulated–.

Conclusion

Handball players seemed to have different nutritional needs for Zn, with differences in the gene expression of Zn transporters compared to controls. Zn intervention in our athletes may have influenced the expression of Zn transporters, indicating a potential increase in Zn transporters expression to mobilize Zn at the cellular level at 8 weeks of Zn intervention.

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补充锌元素的职业手球运动员体内锌转运体的表达概况
导言锌(Zn)的缺乏不仅对人体健康有影响,在体育运动中也会对成绩产生负面影响。本研究的总体目标是评估职业手球运动员在比赛期间的锌状况(通过血浆水平、膳食摄入量和锌转运体的基因表达),并确定锌补充剂的效果。方法:共招募了 22 名参与者,其中 12 名属于对照组(CG),10 名男子手球运动员组成实验组(ATH-G)、基线(即初始条件)和随访(即 8 周训练和比赛后)。结果在锌干预结束时,ATH-G 的血浆锌水平高于 CG(P ≤ 0.010)。此外,与基线时的 CG 相比,在 ATH-G 中观察到锌转运体基因表达谱的差异--多个锌转运体下调(p ≤ 0.05)。结论手球运动员似乎对锌的营养需求不同,与对照组相比,锌转运体的基因表达存在差异。对我们的运动员进行锌干预可能会影响锌转运体的表达,这表明在进行8周的锌干预后,锌转运体的表达可能会增加,从而在细胞水平动员锌。
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来源期刊
CiteScore
6.60
自引率
2.90%
发文量
202
审稿时长
85 days
期刊介绍: The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.
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