Serum HMGB1 in febrile seizures

IF 2 4区医学 Q3 CLINICAL NEUROLOGY Epilepsy Research Pub Date : 2024-05-10 DOI:10.1016/j.eplepsyres.2024.107381

Maria K. Hautala , Kirsi H. Mikkonen , Tytti M.L. Pokka , Sirpa K. Rannikko , Ulla V. Koskela , Heikki M.J. Rantala , Matti K. Uhari , Virpi Glumoff , Heli M. Helander

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Abstract

The role of high-mobility group box 1 (HMGB1) in the pathogenesis of febrile seizures (FSs) is unclear. In our controlled follow-up study, we compared serum levels of HMGB1 (s-HMGB1) in the same individuals after the first FS, during febrile episodes without a FS, after recurrent FS, during healthy periods after FS, and between patients and controls. In all, 122 patients with FSs were included in the final analysis, including 18 with recurrent FSs with a complete follow-up protocol. We recruited 30 febrile children and 18 matched febrile children without seizures as controls. S-HMGB1 was lower in patients with recurrent FSs after the first FS than that in matched febrile control children (median 1.12 μg/L (0.14–2.95) vs 1.79 μg/L (0.33–47.90), P<0.04). We did not find any other differences in s-HMGB1 between the groups. S-HMGB1 did not differ in different types of FSs. We updated a meta-analysis of s-HMGB1 in patients with FSs and found that the differences were significant only in the studies conducted in East Asian populations. We conclude that S-HMGB1 does not seem to be a key factor in the pathogenesis of FSs but differences in HMGB1 concentrations could explain some of the ethnicity related susceptibility to FSs.

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发热性癫痫发作中的血清 HMGB1

高迁移率基团框 1（HMGB1）在发热性癫痫发作（FSs）发病机制中的作用尚不清楚。在我们的对照随访研究中，我们比较了首次 FS 后、未发生 FS 的发热发作期间、复发 FS 后、FS 后的健康期以及患者与对照组之间相同个体的血清 HMGB1（s-HMGB1）水平。最终分析共纳入了 122 名 FS 患者，包括 18 名具有完整随访方案的复发性 FS 患者。我们招募了 30 名发热儿童和 18 名无癫痫发作的匹配发热儿童作为对照。与匹配的发热对照组儿童相比，第一次 FS 后复发性 FS 患者的 S-HMGB1 更低（中位数 1.12 μg/L (0.14-2.95) vs 1.79 μg/L (0.33-47.90)，P<0.04）。我们没有发现各组之间的 s-HMGB1 存在其他差异。S-HMGB1 在不同类型的 FS 中没有差异。我们更新了一项关于 FSs 患者 s-HMGB1 的荟萃分析，发现只有在东亚人群中进行的研究中，s-HMGB1 的差异才具有显著性。我们的结论是，S-HMGB1 似乎不是 FSs 发病机制的关键因素，但 HMGB1 浓度的差异可以解释与种族有关的 FSs 易感性。

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.