Vancomycin bioanalysis for TDM services by using immunoassay and HPLC: A scoping review

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES Pharmacy Education Pub Date : 2024-05-01 DOI:10.46542/pe.2024.243.197203

V. Ningrum, Senya Puteri Amalia, Ari Wibowo

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Abstract

Background: Administration of vancomycin in treating infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) requires therapeutic drug monitoring (TDM). The immunoassay method and high-performance liquid chromatography (HPLC) are the two methods of choice for examining vancomycin levels, with their respective advantages. Objective: This study aims to review the validity of immunoassay and HPLC methods, as well as consider which method is appropriate, effective, and efficient for TDM in the clinical setting. Method: Related articles were searched for using the keywords "immunoassay", "vancomycin", "HPLC", "bioanalysis", and "human" in the PubMed, Google Scholar, and Science Direct databases. Result: A total of 20 publications examined immunoassays, whereas 23 articles covered HPLC. Both the immunoassay and HPLC methods provided acceptable bioanalytical validation values. Conclusion: The immunoassay method is an option for routine sample analysis that requires fast results, but this method is not recommended for patients with high immunoglobulin levels. The HPLC method is a choice because it offers better selectivity and sensitivity.

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利用免疫测定和高效液相色谱法对万古霉素进行生物分析，以提供 TDM 服务：范围审查

背景：使用万古霉素治疗耐甲氧西林金黄色葡萄球菌（MRSA）引起的感染需要进行治疗药物监测（TDM）。免疫测定法和高效液相色谱法（HPLC）是检测万古霉素水平的两种首选方法，各有优势：本研究旨在回顾免疫测定法和高效液相色谱法的有效性，并考虑哪种方法适合、有效且高效地用于临床环境中的 TDM：在 PubMed、Google Scholar 和 Science Direct 数据库中以 "免疫测定"、"万古霉素"、"高效液相色谱"、"生物分析 "和 "人类 "为关键词搜索相关文章：结果：共有 20 篇文章研究了免疫测定，23 篇文章研究了高效液相色谱。免疫测定法和高效液相色谱法都提供了可接受的生物分析验证值：免疫测定法是需要快速得出结果的常规样本分析的一种选择，但不建议免疫球蛋白水平较高的患者使用这种方法。高效液相色谱法具有更好的选择性和灵敏度，可作为一种选择。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.