The potential role of the p75 receptor in schizophrenia: neuroimmunomodulation and making life or death decisions

IF 3.7 Q2 IMMUNOLOGY Brain, behavior, & immunity - health Pub Date : 2024-05-14 DOI:10.1016/j.bbih.2024.100796
Jessica Chandra
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Abstract

The nerve growth factor receptor, also referred to as tumour necrosis factor II and the p75 neurotrophin receptor (p75), serves pleiotropic functions in both the peripheral and central nervous system, involving modulation of immune responses, cell survival and cell death signalling in response to multiple ligands including cytokines such as TNFα, as well as proneurotrophins and mature neurotrophins. Whilst in vitro and in vivo studies have characterised various responses of the p75 receptor in isolated conditions, it remains unclear whether the p75 receptor serves to provide neuroprotection or contributes to neurotoxicity in neuroinflammatory and neurotrophin-deficit conditions, such as those presenting in schizophrenia. The purpose of this mini-review is to characterise the potential signalling mechanisms of the p75 receptor respective to neuropathological changes prevailing in schizophrenia to ultimately propose how specific functions of the receptor may underlie altered levels of p75 in specific cell types. On the basis of this evaluation, this mini-review aims to promote avenues for future research in utilising the therapeutic potential of ligands for the p75 receptor in psychiatric disorders, whereby heightened inflammation and reductions in trophic signalling mechanisms coalesce in the brain, potentially resulting in tissue damage.

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p75 受体在精神分裂症中的潜在作用:神经免疫调节与生死抉择
神经生长因子受体又称肿瘤坏死因子 II 和 p75 神经营养素受体(p75),在外周和中枢神经系统中发挥着多种功能,包括调节免疫反应、细胞存活和细胞死亡信号,以应对多种配体,包括 TNFα 等细胞因子以及前神经营养素和成熟神经营养素。虽然体外和体内研究已经描述了 p75 受体在孤立条件下的各种反应,但目前仍不清楚 p75 受体在神经炎症和神经营养素缺乏的情况下(如精神分裂症)是提供神经保护还是导致神经毒性。本微型综述旨在描述 p75 受体与精神分裂症神经病理学变化相关的潜在信号机制,最终提出受体的特定功能如何可能导致特定细胞类型中 p75 水平的改变。在这一评估的基础上,本微型综述旨在促进未来研究的途径,在精神疾病中利用 p75 受体配体的治疗潜力,因为在精神疾病中,大脑中的炎症加剧和营养信号机制的减少共同作用,可能导致组织损伤。
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
发文量
0
审稿时长
97 days
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