A. Goto, Y. Anraku, Shigeto Fukushima, Akihiro Kishimura
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引用次数: 0
Abstract
Polyion complex vesicles (PICsomes) possess several features that render them as suitable for drug delivery systems. However, retaining water-soluble low-molecular-weight compounds (WLMWCs) remains challenging because of the high permeability of their vesicular membranes. Herein, we propose a new approach for prolonged retention and sustained release of WLMWCs from PICsomes by loading hydroxypropyl methylcellulose to increase the viscosity of the inner aqueous phase. The PICsomes retained 2% to 4% of the WLMWCs, and 100% of the WLMWCs were released within 96 h according to first-order kinetics.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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