Effect of novel composite materials on human injury and rehabilitation training in athletic long jump sports

IF 0.7 4区 材料科学 Q3 Materials Science Materials Express Pub Date : 2024-05-01 DOI:10.1166/mex.2024.2666
Yu’e Liu, Yuyan Liu
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Abstract

Articular cartilage injuries are prevalent in track and field long jump and can affect an athlete’s health. However, current therapeutic options cannot effectively repair the damaged cartilage tissue. It is important to find alternative treatment methods that can provide better results for injured athletes. In this study, carbon nanofibers (CNFs) were employed to enhance the properties of hyaluronic acid (HA) and develop nanocomposite hydrogel scaffolds. Bone marrow mesenchymal stem cells extracted from the joints of experimental mice were subsequently loaded onto the CNFs-HA scaffolds and evaluated for bioactivity and repair capacity. The TEM photographs of CNFs-MA displayed an orderly arrangement of fibers. Observing the FT-IR spectral characteristics of CNFs-MA revealed a telescopic vibration peak at 1700 cm−1. CNFs-HA demonstrated a rapid increase in cartilage damage repair score after 15 days, and at 1 month, the joint damage repair score of CNFs-HA was significantly different from that of pure HA and the untreated group. Based on the foregoing results, it can be inferred that CNFs-HA, as prepared, is biocompatible and efficacious in treating articular cartilage tissue injury. Furthermore, this study this study provides a reliable solution for cartilage injury treatment and establishes an experimental basis for its clinical management.
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新型复合材料对跳远运动中人体损伤和康复训练的影响
关节软骨损伤是田径跳远运动中的常见伤,会影响运动员的健康。然而,目前的治疗方案无法有效修复受损的软骨组织。因此,找到能为受伤运动员提供更好治疗效果的替代治疗方法非常重要。本研究采用碳纳米纤维(CNFs)来增强透明质酸(HA)的特性,并开发出纳米复合水凝胶支架。随后将从实验小鼠关节中提取的骨髓间充质干细胞负载到 CNFs-HA 支架上,并评估其生物活性和修复能力。CNFs-MA 的 TEM 照片显示纤维排列有序。通过观察 CNFs-MA 的傅立叶变换红外光谱特征,发现其在 1700 cm-1 处有一个伸缩振动峰。15 天后,CNFs-HA 的软骨损伤修复评分迅速上升,1 个月后,CNFs-HA 的关节损伤修复评分与纯 HA 和未处理组相比有显著差异。基于上述结果,可以推断所制备的 CNFs-HA 具有良好的生物相容性和治疗关节软骨组织损伤的功效。此外,该研究还为软骨损伤治疗提供了可靠的解决方案,为临床治疗奠定了实验基础。
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来源期刊
Materials Express
Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
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69
审稿时长
>12 weeks
期刊介绍: Information not localized
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