Investigating the role of axonal ion channel cooperativity in action potential dynamics: Studies on Hodgkin-Huxley's model

IF 3.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biophysical chemistry Pub Date : 2024-05-08 DOI:10.1016/j.bpc.2024.107257
Jitender Kumar , Patrick Das Gupta , Subhendu Ghosh
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Abstract

Voltage-gated ion channels play an important role in generating action potential in neurons. These ion channels are found to be in localized cluster form on the axonal membrane surface and behave cooperatively. However, in Hodgkin & Huxley's model of action potential the ion channels are considered to function independently. According to some recent reports, the activity of an ion channel is influenced by the neighboring ion channels' activities. We have modified the Hodgkin-Huxley's model based on our previous studies on cooperativity among ion channels. Computational analysis of the proposed model shows that the initiation of the action potential, amplitude and hyperpolarization are affected significantly by the cooperative interactions among the voltage-gated ion channels present on the axonal membrane surface. These results are qualitatively supported by the existing experimental facts.

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研究轴突离子通道合作性在动作电位动力学中的作用:霍奇金-赫胥黎模型研究
电压门控离子通道在神经元产生动作电位的过程中发挥着重要作用。人们发现这些离子通道在轴突膜表面以局部集群的形式存在,并且相互配合。然而,在霍奇金与赫胥黎的动作电位模型中,离子通道被认为是独立发挥作用的。根据最近的一些报道,一个离子通道的活性受相邻离子通道活性的影响。我们根据之前对离子通道间合作性的研究,对霍奇金-赫胥黎模型进行了修改。对所提出模型的计算分析表明,轴突膜表面的电压门控离子通道之间的合作性相互作用对动作电位的启动、振幅和超极化有显著影响。这些结果得到了现有实验事实的定性支持。
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来源期刊
Biophysical chemistry
Biophysical chemistry 生物-生化与分子生物学
CiteScore
6.10
自引率
10.50%
发文量
121
审稿时长
20 days
期刊介绍: Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.
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