Neutrophil-to-lymphocyte ratio in colorectal tissue affects prognosis in patients with colorectal cancer

IF 3.6 3区医学 Q1 PATHOLOGY Pathology Pub Date : 2024-05-15 DOI:10.1016/j.pathol.2024.03.003

Feng Xun , Wenliang Jiang , Min Sha , Wenya Wang , Yong Xia , Haoran Hu , Rongquan Liu , Hong Yu , Honggang Wang

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Abstract

The objective of this investigation was to analyse the correlation between the neutrophil-to-lymphocyte ratio (NLR) status in the immune microenvironment (IME) and the prognostic outcomes of patients who have undergone radical surgery for colorectal cancer (CRC).

In light of the continued prevalence of CRC in China, this study utilised Kaplan–Meier and Cox regression analyses to assess the prognostic relevance of NLR status in IME among patients with CRC. Furthermore, cellular experiments, such as cell scratching, were conducted to elucidate the underlying mechanisms of NLR's impact on CRC.

The NLR status in IME has been found to have a significant impact on the prognosis of patients with CRC. Patients who exhibit elevated intratumoural and extratumoural NLR are associated with a poor prognosis. Experimental evidence indicates that tumour-associated neutrophil (TAN) augments the migratory, invasive, and proliferative potential of HT-29, HCT-116 and LOVO colorectal cancer cells, while concurrently reducing their sensitivity to oxaliplatin. Conversely, lymphocytes have demonstrated cytotoxic effects on HT-29 cells.

The NLR status in IME may serve as a prognostic biomarker for resectable CRC.

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结直肠组织中的中性粒细胞与淋巴细胞比率影响结直肠癌患者的预后

本研究旨在分析免疫微环境（IME）中的中性粒细胞与淋巴细胞比值（NLR）状态与结直肠癌（CRC）根治术患者预后结果之间的相关性。鉴于CRC在中国的持续流行，本研究采用Kaplan-Meier和Cox回归分析法评估IME中NLR状态与CRC患者预后的相关性。此外，研究还进行了细胞搔抓等细胞实验，以阐明 NLR 对 CRC 影响的内在机制。肿瘤内和肿瘤外 NLR 升高的患者预后较差。实验证据表明，肿瘤相关中性粒细胞（TAN）增强了 HT-29、HCT-116 和 LOVO 大肠癌细胞的迁移、侵袭和增殖潜力，同时降低了它们对奥沙利铂的敏感性。相反，淋巴细胞对 HT-29 细胞具有细胞毒性作用。IME 中的 NLR 状态可作为可切除 CRC 的预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology 医学-病理学

CiteScore

6.50

自引率

2.20%

发文量

459

审稿时长

54 days

期刊介绍： Published by Elsevier from 2016 Pathology is the official journal of the Royal College of Pathologists of Australasia (RCPA). It is committed to publishing peer-reviewed, original articles related to the science of pathology in its broadest sense, including anatomical pathology, chemical pathology and biochemistry, cytopathology, experimental pathology, forensic pathology and morbid anatomy, genetics, haematology, immunology and immunopathology, microbiology and molecular pathology.