Simple and efficient synthesis of pyrrolo[3,2-f]quinoxaline derivatives via three-component reaction

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC Journal of Heterocyclic Chemistry Pub Date : 2024-05-18 DOI:10.1002/jhet.4822

Dan-Dan Wan, Yu-heng Qian, Jia-Yan Liu, Dong-Sheng Chen

引用次数: 0

Abstract

A series of pyrrolo[3,2-f]quinoxaline derivatives have been obtained by a three-component domino reaction of quinoxalin-6-amine, arylglyoxal monohydrates, and cyclic 1,3-dicarbonyl compounds in ethanol medium at 80°C catalyzed by acetic acid. The notable features of this synthesis are excellent regioselectivity, operational simplicity, relatively mild reaction conditions, and good yields.

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通过三组分反应简单高效地合成吡咯并[3,2-f]喹喔啉衍生物

在乙酸催化下，喹喔啉-6-胺、芳基乙二醛一水合物和环状 1,3-二羰基化合物在 80°C 的乙醇介质中发生三组份多米诺反应，得到了一系列吡咯并[3,2-f]喹喔啉衍生物。这种合成方法的显著特点是具有极佳的区域选择性、操作简单、反应条件相对温和以及收率高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.

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