Toxicity Research Progress of Nickel Oxide Nanoparticles Exposure in the Environment

IF 6.4 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Current Pollution Reports Pub Date : 2024-05-18 DOI:10.1007/s40726-024-00306-w
Caixia Bai, Zhihao Zhang, Donggang Guo, Quanxi Zhang
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Abstract

Purpose of Review

Nickel oxide nanoparticles (NiO NPs) have attracted considerable interest in multiple industries because of their distinct properties and wide range of potential applications. However, concerns regarding their potential adverse health effects have prompted extensive research efforts to understand their toxicity and develop appropriate safety guidelines.

Recent Findings

Recent studies have demonstrated that exposure to NiO NPs can induce harm in a variety of animal models, plants, ecological systems, and in vitro cell models. Research on the mechanism of signaling pathways implicated in respiratory system toxicity and hepatotoxicity has shown that NiO NPs can lead to organ damage by triggering downstream signaling through the nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPK)/Smad, phosphoinositide 3-kinase (PI3K/AKT), and hedgehog signaling pathways. High-throughput RNA sequencing has been used in toxicity studies to detect important changes in the transcriptome at the mRNA and pathway levels. Additionally, NiO NPs have been found to cause NiO NPs induce neurotoxicity, genotoxicity, and ecotoxicity in plants and earthworms, potentially through mechanisms involving oxidative stress and inflammatory factors.

Summary

This review provides a comprehensive summary of current research progress on the health effects of NiO NPs, focusing on their application, routes of exposure, and potential toxicity mechanisms. The study also evaluates evidence on the impact of NiO NPs on organ systems, including the respiratory, liver, nervous, genotoxic, reproductive and developmental effects. Lastly, the review suggests further research directions to improve understanding of the toxic effects and mechanisms of NiO NPs for safer application.

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环境中氧化镍纳米颗粒暴露的毒性研究进展
综述目的氧化镍纳米粒子(NiO NPs)因其独特的性质和广泛的潜在应用而引起了多个行业的浓厚兴趣。最近的研究结果最近的研究结果表明,暴露于氧化镍纳米粒子会对各种动物模型、植物、生态系统和体外细胞模型造成伤害。有关呼吸系统毒性和肝毒性信号通路机制的研究表明,NiO NPs 可通过核因子卡巴-B (NF-κB)、丝裂原活化蛋白激酶 (MAPK)/Smad、磷酸肌醇 3- 激酶 (PI3K/AKT) 和刺猬信号通路触发下游信号,从而导致器官损伤。高通量 RNA 测序已被用于毒性研究,以检测转录组在 mRNA 和通路水平上的重要变化。本综述全面总结了目前有关氧化镍氮氧化物对健康影响的研究进展,重点介绍了氧化镍氮氧化物的应用、暴露途径和潜在毒性机制。研究还评估了有关氧化镍氮氧化物对器官系统影响的证据,包括对呼吸系统、肝脏、神经系统、基因毒性、生殖和发育的影响。最后,该综述提出了进一步的研究方向,以加深对氧化镍氮氧化物毒性效应和机制的了解,从而更安全地应用氧化镍氮氧化物。
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来源期刊
Current Pollution Reports
Current Pollution Reports Environmental Science-Water Science and Technology
CiteScore
12.10
自引率
1.40%
发文量
31
期刊介绍: Current Pollution Reports provides in-depth review articles contributed by international experts on the most significant developments in the field of environmental pollution.By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to identification, characterization, treatment, management of pollutants and much more.
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