Selene F H Shore, Florian H Leinberger, Elizabeth M Fozo, Bork A Berghoff
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引用次数: 0
Abstract
Toxin-antitoxin systems are ubiquitous in the prokaryotic world and widely distributed among chromosomes and mobile genetic elements. Several different toxin-antitoxin system types exist, but what they all have in common is that toxin activity is prevented by the cognate antitoxin. In type I toxin-antitoxin systems, toxin production is controlled by an RNA antitoxin and by structural features inherent to the toxin messenger RNA. Most type I toxins are small membrane proteins that display a variety of cellular effects. While originally discovered as modules that stabilize plasmids, chromosomal type I toxin-antitoxin systems may also stabilize prophages, or serve important functions upon certain stress conditions and contribute to population-wide survival strategies. Here, we will describe the intricate RNA-based regulation of type I toxin-antitoxin systems and discuss their potential biological functions.
毒素-抗毒素系统在原核生物中无处不在，广泛分布于染色体和移动遗传因子中。毒素-抗毒素系统有几种不同的类型，但它们的共同点都是毒素活性被同源的抗毒素所阻止。在 I 型毒素-抗毒素系统中，毒素的产生受 RNA 抗毒素和毒素信使 RNA 固有结构特征的控制。大多数 I 型毒素都是小型膜蛋白，能产生多种细胞效应。虽然最初是作为稳定质粒的模块被发现的，但染色体 I 型毒素-抗毒素系统也可能稳定原生质粒，或在某些应激条件下发挥重要功能，并有助于整个种群的生存策略。在这里，我们将描述 I 型毒素-抗毒素系统基于 RNA 的复杂调控，并讨论其潜在的生物学功能。
EcoSal PlusImmunology and Microbiology-Microbiology
CiteScore
12.20
自引率
0.00%
发文量
4
期刊介绍：
EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.
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