A Comprehensive Review on the Significance of Cysteine in Various Metabolic Disorders; Particularly CVD, Diabetes, Renal Dysfunction, and Ischemic Stroke.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.2174/0113892037287215240424090908
Namra Aziz, Pranay Wal, Rishika Sinha, Prashant Ramesh Shirode, GunoSindhu Chakraborthy, Mukesh Chandra Sharma, Pankaj Kumar
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Abstract

Metabolic disorders have long been a challenge for medical professionals and are a leading cause of mortality in adults. Diabetes, cardiovascular disorders (CVD), renal dysfunction, and ischemic stroke are the most prevalent ailments contributing to a high mortality rate worldwide. Reactive oxygen species are one of the leading factors that act as a fundamental root cause of metabolic syndrome. All of these disorders have their respective treatments, which, to some degree, sabotage the pathological worsening of the disease and an inevitable death. However, they pose a perilous health hazard to humankind. Cysteine, a functional amino acid shows promise for the prevention and treatment of metabolic disorders, such as CVD, Diabetes mellitus, renal dysfunction, and ischemic stroke. In this review, we explored whether cysteine can eradicate reactive oxygen species and subsequently prevent and treat these diseases.

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全面回顾半胱氨酸在各种代谢紊乱,尤其是心血管疾病、糖尿病、肾功能障碍和缺血性中风中的重要作用。
长期以来,代谢紊乱一直是医学专家面临的难题,也是导致成人死亡的主要原因之一。糖尿病、心血管疾病(CVD)、肾功能障碍和缺血性中风是导致全球高死亡率的最常见疾病。活性氧是导致代谢综合征的主要因素之一。所有这些疾病都有各自的治疗方法,在一定程度上可以阻止疾病的病理恶化和不可避免的死亡。然而,它们对人类的健康构成了危险的威胁。半胱氨酸作为一种功能性氨基酸,在预防和治疗心血管疾病、糖尿病、肾功能障碍和缺血性中风等代谢性疾病方面大有可为。在这篇综述中,我们探讨了半胱氨酸能否消除活性氧,进而预防和治疗这些疾病。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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