Jian Ma , Xiaotong Wang , Yuewang Jia , Fangyan Tan , Xin Yuan , Jianlin Du
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引用次数: 0
Abstract
Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGFβ1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets.
心脏受损会启动修复过程，导致心脏重塑。B 细胞在这一过程中发挥着重要作用。B 细胞被招募到受伤部位，通过分泌抗体和细胞因子激活心脏重塑。不同类型的 B 细胞在心脏中表现出特定的功能。在所有类型的 B 细胞中，心脏相关 B 细胞通过分泌 TGFβ1 在心脏中发挥重要作用。B 细胞参与成纤维细胞的活化，促进心脏纤维化。心脏中 B 细胞的四种亚型揭示了 B 细胞的异质性与心脏重塑之间的关系。许多心血管疾病，如动脉粥样硬化、心力衰竭（HF）、高血压、心肌梗塞（MI）和扩张型心肌病（DCM）都与 B 细胞有关。本综述将讨论这些 B 细胞相关活动的主要机制，并可能提出潜在的新治疗靶点。
期刊介绍：
Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable. Examples include, but are not restricted to:
Infection, autoimmunity, transplantation, immunodeficiencies, inflammation and tumor immunology
Mechanisms of induction, regulation and termination of innate and adaptive immunity
Intercellular communication, cooperation and regulation
Intracellular mechanisms of immunity (endocytosis, protein trafficking, pathogen recognition, antigen presentation, etc)
Mechanisms of action of the cells and molecules of the immune system
Structural analysis
Development of the immune system
Comparative immunology and evolution of the immune system
"Omics" studies and bioinformatics
Vaccines, biotechnology and therapeutic manipulation of the immune system (therapeutic antibodies, cytokines, cellular therapies, etc)
Technical developments.
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